2. Academic Validation
  3. Overexpression of TECPR1 improved cognitive function of P301S-tau mice via activation of autophagy in the early and late process

Overexpression of TECPR1 improved cognitive function of P301S-tau mice via activation of autophagy in the early and late process

  • Aging Cell. 2024 Nov 7:e14404. doi: 10.1111/acel.14404.
Ting Li 1 2,  Ruijuan Liu 2,  Ye He 2,  Bingge Zhang 2,  Xuexiang Rui 2,  Xifei Yang 3,  Jian-Zhi Wang 2,  Juan Zeng 1,  Gang Li 4,  Xiao Li 5,  Gong-Ping Liu 2 3 6
Affiliations

Affiliations

  • 1 Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, China.
  • 2 Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China and Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • 3 Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Subject of Modern Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
  • 4 Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • 5 Department of Pathology, Wuhan No. 1 Hospital, Wuhan, China.
  • 6 Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China.
PMID: 39511758 DOI: 10.1111/acel.14404
Abstract

Autophagy disorders in AD patients and animal models were well known, however, the effect of P301S-tau on Autophagy is not clear. Here, we found that Autophagy related protein Tectonin Beta-Propeller Repeat-Containing Protein 1 (TECPR1) decreased in the hippocampus of P301S-tau transgenic mice by proteomics, which was proved in vivo and in vitro, and P301S-tau induced autophagic deficits in early and late process. TECPR1 overexpression attenuated P301S-tau induced Autophagy defects via promoting autophagosome generation and autophagosome and lysosomes fusion. We also found that TECPR1 overexpression ameliorated the behavior disorders of P301S-tau mice with promoting tau degradation, improving synaptic plasticity and neuron loss. Lastly, CQ or 3-MA treatment reversed TECPR1 induced improvement effects on autophagic and cognitive disorders, further proved that, TECPR1 activated the early and late process of Autophagy to ameliorate the cognition of P301S-tau mice. Our data suggest that TECPR1 is a potential therapy target for AD.

Keywords

TECPR1; autophagy; cognitive function; synapse; tau.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z