2. Academic Validation
  3. CBX2 promotes cervical cancer cell proliferation and resistance to DNA-damaging treatment via maintaining cancer stemness

CBX2 promotes cervical cancer cell proliferation and resistance to DNA-damaging treatment via maintaining cancer stemness

  • J Biol Chem. 2025 Feb;301(2):108170. doi: 10.1016/j.jbc.2025.108170.
Wenhan Li 1,  Ru Shi 2,  Yumei Gao 1,  Xiaoman Wang 1,  Tiantian Shen 1,  Xiaoli Liu 1,  Qiulei Wu 1,  Xiaohan Xu 3,  Zanhong Wang 4,  Shi Du 1,  Si Sun 1,  Lu Yang 1,  Jing Cai 5,  Lin Liu 6
Affiliations

Affiliations

  • 1 Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • 2 Department of Obstetrics and Gynecology, Shanxi Children's Hospital, Shanxi Maternal and Child Health Hospital, Taiyuan, Shanxi, China.
  • 3 Department of Gynecology, Qingdao Municipal Hospital, Qingdao, China.
  • 4 Department of Obstetrics and Gynecology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.
  • 5 Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: jingcai@hust.edu.cn.
  • 6 Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: linliu_whxh@hust.edu.cn.
PMID: 39793896 DOI: 10.1016/j.jbc.2025.108170
Abstract

Cervical Cancer is the fourth most common malignancy and the fourth leading cause of cancer-related death among women. Advanced stages and resistance to treatment in cervical Cancer induce cancer-related deaths. Although Epigenetics has been known to play a vital role in tumor progression and resistance, the function of epigenetic regulators in cervical Cancer is an area of investigation. In this study, we focused on an epigenetic regulator, polycomb repressor complex 1 in cervical Cancer. Through bioinformatics analysis and immunochemistry, we subsequently identified chromobox 2CBX2), the deregulated subunit of polycomb repressor complex 1, which is upregulated in cervical Cancer and associated with poor prognosis and unfavorable clinicopathological characteristics. We provided functional evidence demonstrating that CBX2 promoted cervical Cancer cell proliferation. Furthermore, CBX2 exhibited an antiapoptotic effect, which induced resistance to cisplatin and ionizing radiation in cervical Cancer cells. Moreover, CBX2 was involved in maintaining Cancer stemness. These findings suggest that CBX2 plays an important role in cervical Cancer progression and resistance to treatment, and may serve as a potential biomarker for prognosis and resistance as well as a potential therapeutic target.

Keywords

PRC1; cervical carcinoma; chemoresistance; radioresistance; tumor proliferation.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z