2. Academic Validation
  3. Astragaloside IV attenuates cadmium induced nephrotoxicity in rats by activating Nrf2

Astragaloside IV attenuates cadmium induced nephrotoxicity in rats by activating Nrf2

  • Sci Rep. 2025 Jan 15;15(1):2028. doi: 10.1038/s41598-025-86312-4.
Yuchen Li # 1,  Jiayi Zhou # 2 3,  Tianxin Zhang 1,  Xiaocong Li 1,  Cheng Wu 4,  Ziyi Zhao 5,  Jianyuan Tang 5,  Xiaoyu Tan 6,  Qiongying Hu 7,  Wenhao Liao 8
Affiliations

Affiliations

  • 1 Department of Laboratory Medicine, Hospital of Chengdu University of Traditional Chinese medicine, Chengdu, China.
  • 2 School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
  • 3 Department of Emergency, Sichuan Province Forestry Center Hospital, Chengdu, China.
  • 4 Department of Pathology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • 5 Traditional Chinese Medicine Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Chengdu, China.
  • 6 Department of Laboratory Medicine, Hospital of Chengdu University of Traditional Chinese medicine, Chengdu, China. 547913973@qq.com.
  • 7 Department of Laboratory Medicine, Hospital of Chengdu University of Traditional Chinese medicine, Chengdu, China. qiongyinghu@163.com.
  • 8 Department of Nephrology, the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University, (Third Military Medical University), Chongqing, China. liaowenhao@stu.cdutcm.edu.cn.
  • # Contributed equally.
PMID: 39815001 DOI: 10.1038/s41598-025-86312-4
Abstract

Acute kidney injury (AKI) has become a disease of global concern due to its high morbidity and mortality. This has highlighted the need for renoprotective agents. Astragaloside IV (AS-IV) is a saponin isolated from Astragalus membranaceus with good antioxidant, anti-inflammatory and anti-tumor properties. In this study, HK2 cells and rat model were utilized to explore the protective effect of AS-IV against cadmium chloride-induced oxidative stress-induced Apoptosis. CdCl2-induced Apoptosis, ROS production, and mitochondrial membrane potential alterations were significantly inhibited in AS-IV -treated HK2 cells. Expression of the mitochondria-associated apoptotic proteins Cleaved-Caspase3, Cleaved-Caspase9, and Cleaved-PARP was significantly reduced after AS-IV intervention. In addition, AS-IV inhibited Rat weight loss and also alleviated the symptoms of CdCl2-induced nephrotoxicity in a rat model of CdCl2-induced kidney injury. Further experiments showed that AS-IV suppresses heavy metal Cd-induced mitochondria-mediated Apoptosis by regulating the Nrf2/HO-1 pathway. In conclusion, AS-IV could protect the kidney from heavy metal-induced toxicity and could be used as a nephroprotective agent.

Keywords

Astragaloside IV; Acute kidney injury; Apoptosis; Heavy metal cadmium; Oxidative stress.

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