2. Academic Validation
  3. Discovery of Small Molecules that Bind to Son of Sevenless 2 (SOS2)

Discovery of Small Molecules that Bind to Son of Sevenless 2 (SOS2)

  • J Med Chem. 2025 Feb 13;68(3):2680-2693. doi: 10.1021/acs.jmedchem.4c02007.
Krzysztof M Zak 1,  Alex G Waterson 2,  Leonhard Geist 1,  Nina Braun 1,  Katja Hauer 1,  Klaus Rumpel 1,  Juergen Ramharter 1,  Heinz Stadtmueller 1,  Bernhard Wolkerstorfer 1,  David Schoenbauer 1,  Jianwen Cui 3,  Jason Phan 3,  Jason R Abbott 3,  Dhruba Sarkar 3,  Timothy R Hodges 3,  Allison Arnold 3,  John L Sensintaffar 3,  Stephen W Fesik 2 3,  Dirk Kessler 1
Affiliations

Affiliations

  • 1 Boehringer Ingelheim RCV GmbH & Co. KG, A-1121 Vienna, Austria.
  • 2 Departments of Pharmacology and Chemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
  • 3 Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
PMID: 39818983 DOI: 10.1021/acs.jmedchem.4c02007
Abstract

The Son of Sevenless (SOS) protein family includes two highly homologous proteins, SOS1 and SOS2, that act as guanine nucleotide exchange factors (GEFs) for Ras proteins. They catalyze the GDP-to-GTP exchange, resulting in an increase of the active GTP-bound form of Ras. Despite highly similar structures and expression patterns, SOS1 is generally accepted as the dominant Ras GEF for downstream signaling in pathological states. Nonetheless, SOS2 has been reported to critically impact the RAS-PI3K/Akt signaling axis, especially in KRAS-driven Cancer cell lines and in the absence of SOS1. Hence, therapeutic targeting of SOS2 may be an attractive strategy to target RAS-driven malignancies. Herein, we report the discovery and initial optimization of a selective quinazoline-based compound series that binds with micromolar affinity to the catalytic site of SOS2. We also disclose an additional, previously unreported binding site on SOS2 occupied by a different small molecule class.

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