2. Academic Validation
  3. Directional Freeze-Casting Cryogel Loaded with Quaternized Chitosan Modified Gallium Metal-Organic Frameworks to Capture and Eradicate the Resistant Bacteria for Guided Regeneration in Infected Bone Defects

Directional Freeze-Casting Cryogel Loaded with Quaternized Chitosan Modified Gallium Metal-Organic Frameworks to Capture and Eradicate the Resistant Bacteria for Guided Regeneration in Infected Bone Defects

  • Adv Mater. 2025 Jan 23:e2414437. doi: 10.1002/adma.202414437.
Yihao Liu 1,  Kai Yuan 1 2,  Yixuan Lin 1,  Yiqi Yang 3,  Weiqing Kong 4,  Jing Shan 5,  Haoyi Niu 1,  Weize Kong 1,  Fupeng Li 1,  Xiaokun Yue 1,  Yun Du 1,  Yakun Liang 6,  Haishuang Chang 6,  Zhifeng Yu 1,  Jinwu Wang 1,  Guangzheng Yang 7,  Lingyan Cao 7,  Kai Huang 1,  Shengbing Yang 1,  Tingting Tang 1
Affiliations

Affiliations

  • 1 Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, P. R. China.
  • 2 Department of Bone and Joint Surgery, Department of Orthopedics, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, P. R. China.
  • 3 Department of Orthopedics, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Rd, Hangzhou, 310003, P. R. China.
  • 4 Department of Orthopedic Surgery, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, 199Jiefang South Road, Xuzhou, 221009, P. R. China.
  • 5 School of Pharmacy, The University of Sydney, Sydney, NSW, 2006, Australia.
  • 6 Shanghai Institute of Precision Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200125, P. R. China.
  • 7 Department of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, P. R. China.
PMID: 39846310 DOI: 10.1002/adma.202414437
Abstract

Antimicrobial resistance and impaired bone regeneration are the great challenges in treating infected bone defects. Its recurrent and resistant nature, high incidence rate, long-term hospitalization, and high medical costs have driven the efforts of the scientific community to develop new therapies to improve the situation. Considering the complex microenvironment and persistent mechanisms mediated by resistant bacteria, it is crucial to develop an implant with enhanced osseointegration and sustained and effective Infection clearance effects. Here, a positively charged quaternized chitosan (QCS) coated gallium-based metal-organic framework (GaMOF) is designed, to capture the antibiotic-resistant bacteria (Methicillin-resistant Staphylococcus aureus, MRSA) as a "captor", and rejuvenate Methicillin (Me) via disturbing the tricarboxylic acid (TCA) cycle. Then, a radially oriented porous cryogel loaded with the Me and QCSGaMOF is fabricated by the directional freeze-casting method. The oriented porous structure has an enhanced osseointegration effect by guiding the ingrowth of osteogenic cells. In vitro and in vivo experiments prove the advantages of as-prepared Me/QCSGa-MOF@Cryogel in combating resistant bacteria and guiding bone regeneration in infected bone defects.

Keywords

cryogels; gallium metal–organic frameworks; infected bone defects; methicillin‐resistance staphylococcus aureus (MRSA); quaternized chitosan.

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