2. Academic Validation
  3. A pair of LysM receptors mediates symbiosis and immunity discrimination in Marchantia

A pair of LysM receptors mediates symbiosis and immunity discrimination in Marchantia

  • Cell. 2025 Jan 17:S0092-8674(24)01466-1. doi: 10.1016/j.cell.2024.12.024.
Xinhang Tan 1,  Dapeng Wang 2,  Xiaowei Zhang 2,  Shuang Zheng 1,  Xiaojie Jia 3,  Hui Liu 4,  Zilin Liu 1,  Hao Yang 2,  Huiling Dai 2,  Xi Chen 1,  Zhixin Qian 5,  Ran Wang 6,  Miaolian Ma 2,  Peng Zhang 2,  Nan Yu 5,  Ertao Wang 7
Affiliations

Affiliations

  • 1 New Cornerstone Science Laboratory, Key Laboratory of Plant Carbon Capture, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, SIBS, Chinese Academy of Sciences, Shanghai 200032, China; University of Chinese Academy of Sciences, Beijing 100039, China.
  • 2 New Cornerstone Science Laboratory, Key Laboratory of Plant Carbon Capture, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, SIBS, Chinese Academy of Sciences, Shanghai 200032, China.
  • 3 New Cornerstone Science Laboratory, Key Laboratory of Plant Carbon Capture, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, SIBS, Chinese Academy of Sciences, Shanghai 200032, China; School of Life Sciences and Technology, Shanghai Tech University, Shanghai 201210, China.
  • 4 Germplasm Bank of Wild Species, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
  • 5 College of Life and Environment Sciences, Shanghai Normal University, Shanghai 200234, China.
  • 6 College of Life Sciences, Henan Agricultural University, Zhengzhou 450046, China.
  • 7 New Cornerstone Science Laboratory, Key Laboratory of Plant Carbon Capture, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, SIBS, Chinese Academy of Sciences, Shanghai 200032, China; School of Life Sciences and Technology, Shanghai Tech University, Shanghai 201210, China. Electronic address: etwang@cemps.ac.cn.
PMID: 39855200 DOI: 10.1016/j.cell.2024.12.024
Abstract

Most land Plants form symbioses with microbes to acquire nutrients but also must restrict Infection by pathogens. Here, we show that a single pair of lysin-motif-containing receptor-like kinases, MpaLYR and MpaCERK1, mediates both immunity and symbiosis in the liverwort Marchantia paleacea. MpaLYR has a higher affinity for long-chain (CO7) versus short-chain chitin oligomers (CO4). Although both CO7 and CO4 can activate symbiosis-related genes, CO7 triggers stronger immune responses than CO4 in a dosage-dependent manner. CO4 can inhibit CO7-induced strong immune responses, recapitulating the early response to inoculation with the symbiont arbuscular mycorrhizal fungi. We show that phosphate starvation of Plants increases their production of strigolactone, which stimulates CO4/CO5 secretion from mycorrhizal fungi, thereby prioritizing symbiosis over immunity. Thus, a single pair of LysM receptors mediates dosage-dependent perception of different chitin oligomers to discern symbiotic and pathogenic microbes in M. paleacea, which may facilitate terrestrialization.

Keywords

LysM receptor; MAMPs; Marchantia paleacea; arbuscular mycorrhizal symbiosis; dosage-dependent perception; immunity; phosphate-starvation-triggered symbiosis signaling loop; symbiotic factors.

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