2. Academic Validation
  3. Identification the Cellular Senescence Associated lncRNA LINC01579 in Gastric Cancer

Identification the Cellular Senescence Associated lncRNA LINC01579 in Gastric Cancer

  • J Cell Mol Med. 2025 Jan;29(2):e70360. doi: 10.1111/jcmm.70360.
Jiayong He 1 2,  Ziyi Fu 1 2 3,  Boya Zou 1 2 3 4 5 6,  Xuetao Lei 1 2,  Linhan Lei 1 2,  Qingbin Yang 1 2,  Guoxin Li 1 2 7
Affiliations

Affiliations

  • 1 Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangdong Provincial Engineering Technology Research Center of Minimally Invasive Surgery, Guangzhou, People's Republic of China.
  • 2 Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Guangzhou, People's Republic of China.
  • 3 The First School of Clinical Medicine, Southern Medical University, Guangzhou, People's Republic of China.
  • 4 Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • 5 Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.
  • 6 Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Republic of Korea.
  • 7 Cancer Center of Beijing Tsinghua Changgung Hospital, School of Clinical Medicine,Tsinghua Medicine, Tsinghua University, Beijing, People's Republic of China.
PMID: 39855898 DOI: 10.1111/jcmm.70360
Abstract

Cellular senescence is a key promoter of tumorigenesis and malignant progression. This study aimed to develop a predictive model for assessing cellular senescence in gastric Cancer (GC) outcomes. We identified senescence-related genes and lncRNAs from 375 stomach adenocarcinoma (STAD) patients and established a prognostic senescence score using multivariate COX regression, validated in testing, TCGA-STAD and the combined TCGA-COAD and READ cohorts. The model's predictive efficacy was evaluated across clinical subgroups, tumour microenvironments and immune cell infiltration. A total of 116 senescence-related lncRNAs were filtered, and patients were clustered into two senescent subtypes. The lncRNA signature identified LINC01579 as an independent prognostic factor for GC. Low-risk groups showed prolonged overall survival, increased immune cell infiltration and reduced mutation load. Downregulation of LINC01579 using Antisense Oligonucleotides (ASOs) on normal human fibroblasts decreased cellular proliferation and migration in GC. Collectively, this study established and validated a promising prognostic model connecting senescence-related lncRNAs and clinical outcome in GC and provided potential senescence-related biomarkers for GC prognosis prediction.

Keywords

cellular senescence; fibroblast; gastric cancer; prognosis; tumour microenvironment.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z