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  3. Arctiin suppress Th17 cells response and ameliorates experimental autoimmune uveitis through JAK/STAT signaling

Arctiin suppress Th17 cells response and ameliorates experimental autoimmune uveitis through JAK/STAT signaling

  • Cell Immunol. 2025 Jan 16:409-410:104927. doi: 10.1016/j.cellimm.2025.104927.
Xiao'e Fan 1,  Manhong Xu 2,  Zhengmin Wang 3,  Xiaoyan Sun 4,  Yan Fan 4,  Jiaqi Chen 4,  Junpeng Hao 4,  Ranran Wang 5,  Wei Jia 6
Affiliations

Affiliations

  • 1 Department of Ophthalmology, Jincheng People 's Hospital, Shanxi Province, China. Electronic address: fanxiaoe926@163.com.
  • 2 Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital.
  • 3 Department of Ophthalmology, Jincheng People 's Hospital, Shanxi Province, China; The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
  • 4 Department of Ophthalmology, Jincheng People 's Hospital, Shanxi Province, China.
  • 5 Department of Labotatory, Jincheng People 's Hospital, Shanxi Province, China.
  • 6 Department of Rheumatology, Jincheng People 's Hospital, Shanxi Province, China.
PMID: 39862562 DOI: 10.1016/j.cellimm.2025.104927
Abstract

Conventional treatments for autoimmune uveitis, such as corticosteroids and systemic immunosuppressants, often result in adverse side effects, prompting the need for therapies targeting specific molecular pathways. This study investigates the effects of Arctiin, known for its diverse biological properties, on experimental autoimmune uveitis (EAU) through its action on Th17 cells and the JAK/STAT signaling pathway. Our findings reveal that Arctiin significantly alleviates EAU by reducing clinical scores, inflammatory cell infiltration, and levels of inflammatory cytokines like IL-17 and TNF-α in the eye. Arctiin achieves this by activating Adiponectin Receptor 1 (AdipoR1), which modulates the JAK/STAT pathway, thereby inhibiting Th17 cell differentiation and cytokine secretion. Additionally, Arctiin effectively suppresses IRBP-specific Th17 cell activation in cervical lymph nodes, further mitigating retinal inflammation and tissue damage. These results underscore Arctiin's potential as a therapeutic agent for uveitis and Other autoimmune inflammatory disorders through the modulation of the AdipoR1/JAK/STAT pathway in Th17 cells.

Keywords

Arctiin; Autoimmune uveitis; JAK/STAT signaling pathway; Th17 differentiation.

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