2. Academic Validation
  3. Zirconium oxide nano-catalyzed bis(indolyl)methanes: A sustainable route to anticancer therapies

Zirconium oxide nano-catalyzed bis(indolyl)methanes: A sustainable route to anticancer therapies

  • Bioorg Med Chem Lett. 2025 May 1:120:130132. doi: 10.1016/j.bmcl.2025.130132.
Komal Rathi 1,  Suryakant Kumar 2,  Bidya Bhushan 3,  Varun Rawat 4,  Ashwani Kumar 5,  Aman Bhardwaj 5,  Anand Prakash 2,  Ved Prakash Verma 6
Affiliations

Affiliations

  • 1 Department of Chemistry, Banasthali University, Banasthali Newai 304022, Rajasthan, India.
  • 2 Department of Bioscience and Biotechnology, Banasthali University, Tonk 304022, Rajasthan, India.
  • 3 Department of Pharmaceutical Chemistry, Mallige College of Pharmacy, RGUHS University, Bangalore 560041, Karnataka, India.
  • 4 Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.
  • 5 Department of Education in Science and Mathematics (DESM), Regional Institute of Education, Bhubaneshwar 751022, India.
  • 6 Department of Chemistry, Banasthali University, Banasthali Newai 304022, Rajasthan, India; Department of Education in Science and Mathematics (DESM), Regional Institute of Education, Bhubaneshwar 751022, India. Electronic address: vedprakash079@gmail.com.
PMID: 39923904 DOI: 10.1016/j.bmcl.2025.130132
Abstract

Bis(indolyl)methanes (BIMs) are a class of compounds known for their diverse biological activities, including potential Anticancer properties. Modern synthetic chemistry techniques are examined in this work to develop and manufacture novel Anticancer medications with increased effectiveness and fewer side effects. The cytotoxic efficacy of a moderate and very effective method for creating pharmacologically active BIMs 3a-j using ZrO2 nanoparticles as a catalyst was assessed against the MCF-7 breast Cancer cell line. Remarkably, compounds 3a and 3b exhibited exceptional potency, with IC50 values of 0.17 and 0.13 μM, respectively, surpassing the activity of standard Anticancer agents sorafenib (IC50: 1.23 μM). Another compound 3j demonstrated moderate inhibition effect with an IC50 value of 8.6 μM. These results highlight the potential of BIMs as promising Anticancer agents and warrant further investigation into their mechanism of action and therapeutic applications.

Keywords

Aldehydes; Anticancer activity; Bis(indolyl)methanes; Indole; MCF-7.

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