ONC201-Derived Tetrahydropyridopyrimidindiones as Powerful ClpP Protease Activators to Tackle Diffuse Midline Glioma

Affiliations

• 1 Research Laboratory for Woman and Child Health, Department of Pharmacy─Pharmaceutical Sciences, University of Bari Aldo Moro, 70125 Bari, Italy.
• 2 Laboratory of Molecular Modelling and Heterocyclic Compounds ModHet, Department of Chemical Sciences, University of Catania, 95125 Catania, Italy.
• 3 Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94115, United States.
• 4 Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, 333 Cassell Dr., Baltimore, Maryland 21224, United States.
• 5 Department of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, 70125 Bari, Italy.
• 6 Department of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, 70124 Bari, Italy.
• 7 Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, 70124 Bari, Italy.
• 8 Messina Institute of Technology c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, former Veterinary School, University of Messina, Messina 98168, Italy.
• 9 Chromaleont s.r.l., c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, former Veterinary School, University of Messina, Messina 98168, Italy.