2. Academic Validation
  3. Activity of BAY n 7133 and BAY 1 9139 in vitro and in experimental murine coccidioidomycosis

Activity of BAY n 7133 and BAY 1 9139 in vitro and in experimental murine coccidioidomycosis

  • Eur J Clin Microbiol. 1985 Aug;4(4):400-3. doi: 10.1007/BF02148692.
P D Hoeprich,  J M Merry
PMID: 4043057 DOI: 10.1007/BF02148692
Abstract

The activity of two new Antifungal azoles, BAY n 7133 and BAY 1 9139, against Coccidioides immitis was compared with that of ketoconazole in vitro and in experimental murine coccidioidomycosis. Daily intravenous injections were given for 30 days. All mice were autopsied and suspensions of lung, liver and spleen cultured. BAY n 7133 was as active as ketoconazole while Bay 1 9139 was les active. All three drugs were coccidioidostatic only both in vitro and in vivo.

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