2. Academic Validation
  3. pKa values of estrone, 17 beta-estradiol and 2-methoxyestrone

pKa values of estrone, 17 beta-estradiol and 2-methoxyestrone

  • Steroids. 1979 Nov;34(5):485-99. doi: 10.1016/s0039-128x(79)80011-2.
K M Lewis,  R D Archer
PMID: 516114 DOI: 10.1016/s0039-128x(79)80011-2
Abstract

The acid ionization constants of estrone (10.77), 17 beta-estradiol (10.71) and 2-methoxyestrone (10.81) have been determined spectrophotometrically and shown to be consistent with the additivity of substituent effects of the phenol ring. Previously published values for estrone (10.914) and 17 beta-estradiol (10.078) are shown to be incorrect, at variance with the established trend for Phenols, and inconcsistent with the similarity of the compounds.

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