2. Academic Validation
  3. Synthesis and analgesic activity of some long-acting piperidinospiro derivatives of methadone

Synthesis and analgesic activity of some long-acting piperidinospiro derivatives of methadone

  • J Med Chem. 1978 May;21(5):474-6. doi: 10.1021/jm00203a014.
J M Frincke,  G L Henderson
PMID: 660594 DOI: 10.1021/jm00203a014
Abstract

A congener of methadone, in which the metabolically labile C-6 dimethylamino moiety was replaced with a piperidinospiro derivative, was reduced and acetylated. This conversion produced a marked increase in the duration of analgesia, a trend similar to that found for methadone.

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