2. Academic Validation
  3. Chemical modification of spiramycins. I. Synthesis of the acetal derivatives of neospiramycin I

Chemical modification of spiramycins. I. Synthesis of the acetal derivatives of neospiramycin I

  • J Antibiot (Tokyo). 1983 Oct;36(10):1336-44. doi: 10.7164/antibiotics.36.1336.
H Sano,  M Inoue,  K Yamashita,  R Okachi,  S Omura
PMID: 6643282 DOI: 10.7164/antibiotics.36.1336
Abstract

Tetrahydrofuranyl and tetrahydropyranyl derivatives of neospiramycin I at 3 and/or 4' position were synthesized. In vitro and in vivo activities of these derivatives were correlated with the position and configuration of acetal groups. The most effective derivative, 3-a, 4'-a-di-O-tetrahydrofuranylneospiramycin I was comparable to spiramycin I.

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