Neospiramycin I  (Synonyms: 新螺旋霉素I)

Neospiramycin I is a macrolide antibiotic and a derivative of Spiramycin I (HY-N7141). Neospiramycin I is effective against the macrolide-sensitive KB210 strain of S. aureus, but ineffective against the macrolide-resistant KB224 strain, with minimum inhibitory concentrations (MIC) of 3.12 and greater than 100 µg/mL, respectively; it is also effective against B. cereus, B. subtilis, M. luteus, E. coli, and K. pneumoniae, with respective MIC values of 1.56, 3.12, 3.12, 0.2, 50, and 12.5 µg/mL. Neospiramycin I binds to the ribosomes of E. coli, with an inhibitory concentration 50 (IC₅₀) of 1.2 µM. It protects mice from death in a type III S. pneumoniae infection model, with an effective dose 50 (ED₅₀) of 399.8 mg/kg^[1][2].

698.88

C₃₆H₆₂N₂O₁₁

70253-62-2

新螺旋霉素I

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sano H, et al. Chemical modification of spiramycins. II. Synthesis and antimicrobial activity of 4'-deoxy derivatives of neospiramycin I and their 12-(Z)-isomers. J Antibiot (Tokyo). 1984 Jul;37(7):738-49.  [Content Brief]

  [2]. Sano H, et al. Chemical modification of spiramycins. I. Synthesis of the acetal derivatives of neospiramycin I. J Antibiot (Tokyo). 1983 Oct;36(10):1336-44.  [Content Brief]