2. Academic Validation
  3. In vitro activity of N-formimidoyl thienamycin (MK0787)

In vitro activity of N-formimidoyl thienamycin (MK0787)

  • Antimicrob Agents Chemother. 1980 Oct;18(4):642-4. doi: 10.1128/AAC.18.4.642.
F P Tally,  N V Jacobus,  S L Gorbach
PMID: 6934708 DOI: 10.1128/AAC.18.4.642
Abstract

The in vitro activity of N-formimidoyl thienamycin (MK0787), a stable congener of thienamycin, was determined against 200 species of aerobic and 84 species of anaerobic bacteria. The compound was highly active against resistant gram-negative bacilli, penicillin-resistant Staphylococcus aureus, enterococci, and anaerobic bacteria. The new derivative of thienamycin was more active than the parent compound, probably reflecting the stability of the analog.

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