2. Academic Validation
  3. Identification of 8-dehydrocholesterol (cholesta-5,8-dien-3 beta-ol) in patients with Smith-Lemli-Opitz syndrome

Identification of 8-dehydrocholesterol (cholesta-5,8-dien-3 beta-ol) in patients with Smith-Lemli-Opitz syndrome

  • J Lipid Res. 1995 Apr;36(4):705-13.
A K Batta 1,  G S Tint,  S Shefer,  D Abuelo,  G Salen
Affiliations

Affiliation

  • 1 Department of Medicine, University of Medicine and Dentistry-New Jersey Medical School, Newark 07103, USA.
PMID: 7616117
Abstract

Cholesta-5,8-dien-3 beta-ol (8-dehydrocholesterol) and cholesta-5,7-dien-3 beta-ol (7-dehydrocholesterol) were isolated from the fecal neutral sterol fraction from homozygotes with Smith-Lemli-Opitz syndrome. The structures of the sterols were conclusively established from their mass spectra and 1H and 13C nuclear magnetic resonance spectra. It is probable that 8-dehydrocholesterol arises from 7-dehydrocholesterol and is not a direct precursor of Cholesterol.

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