2. Academic Validation
  3. Binding of quinolizidine alkaloids to nicotinic and muscarinic acetylcholine receptors

Binding of quinolizidine alkaloids to nicotinic and muscarinic acetylcholine receptors

  • J Nat Prod. 1994 Sep;57(9):1316-9. doi: 10.1021/np50111a026.
T Schmeller 1,  M Sauerwein,  F Sporer,  M Wink,  W E Müller
Affiliations

Affiliation

  • 1 Universität Heidelberg, Institut für Pharmazeutische Biologie, Germany.
PMID: 7798968 DOI: 10.1021/np50111a026
Abstract

Fourteen quinolizidine Alkaloids, isolated from Lupinus albus, L. mutabilis, and Anagyris foetida, were analyzed for their affinity for nicotinic and/or muscarinic acetylcholine receptors. Of the compounds tested, the alpha-pyridones, N-methylcytisine and cytisine, showed the highest affinities at the nicotinic receptor, while several quinolizidine alkaloid types were especially active at the muscarinic receptor.

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