2. Academic Validation
  3. Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. II. Structure elucidation of terpendoles A, B, C and D

Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. II. Structure elucidation of terpendoles A, B, C and D

  • J Antibiot (Tokyo). 1995 Jan;48(1):5-11. doi: 10.7164/antibiotics.48.5.
X H Huang 1,  H Nishida,  H Tomoda,  N Tabata,  K Shiomi,  D J Yang,  H Takayanagi,  S Omura
Affiliations

Affiliation

  • 1 Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
PMID: 7868389 DOI: 10.7164/antibiotics.48.5
Abstract

Structures of terpendoles A, B, C and D, novel acyl-CoA: cholesterol Acyltransferase (ACAT) inhibitors, were determined by spectroscopic studies. All terpendoles consist of diterpene and indole moieties in common. Terpendoles A, C and D possess an additional isoprenyl unit via oxygen atom(s) of their diterpene moieties. The relative stereochemistries of terpendoles C and D were confirmed by NOE experiments and X-ray crystallographic analysis.

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