2. Academic Validation
  3. In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum

In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum

  • Antimicrob Agents Chemother. 1994 May;38(5):1169-71. doi: 10.1128/AAC.38.5.1169.
L K Basco 1,  S Mitaku,  A L Skaltsounis,  N Ravelomanantsoa,  F Tillequin,  M Koch,  J Le Bras
Affiliations

Affiliation

  • 1 Laboratoire de Parasitologie, Institut de Médecine et d'Epidémiologie Africaines, Hôpital Bichat-Claude Bernard, Paris, France.
PMID: 8067758 DOI: 10.1128/AAC.38.5.1169
Abstract

The in vitro activities of furo[2,3b]quinoline and Acridone Alkaloids against Plasmodium falciparum were evaluated by an isotopic semimicrotest. A pyran ring in the furoquinoline nucleus and 2-O-pyranoglycoside and 2-nitro substituents in the acridone nucleus improved the antimalarial activities of the compounds. These findings provide a clue for further chemical modifications.

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