2. Academic Validation
  3. Antiinflammatory activity of coumarins from Santolina oblongifolia

Antiinflammatory activity of coumarins from Santolina oblongifolia

  • J Nat Prod. 1996 Dec;59(12):1183-5. doi: 10.1021/np960422f.
A M Silván 1,  M J Abad,  P Bermejo,  M Sollhuber,  A Villar
Affiliations

Affiliation

  • 1 Department of Pharmacology, Faculty of Pharmacy, University Complutense, Madrid, Spain.
PMID: 8988605 DOI: 10.1021/np960422f
Abstract

Four Coumarins were isolated from the EtOAc extract of the flower-tops of Santolina oblongifolia Boiss. (Compositae). They were identified as 7-methoxycoumarin (herniarin) (1), 6,7-dihydroxycoumarin (aesculetin) (2), 6-methoxy-7-glucosidylcoumarin (scopolin) (3), and 6-hydroxy-7-methoxycoumarin (scopoletin) (4). This is the first report of the isolation of aesculetin and scopolin from the genus Santolina. The isolated Coumarins showed marked activity as inhibitors of eicosanoid-release from ionophore-stimulated mouse peritoneal macrophages.

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