1. Academic Validation
  2. The mGlu receptor ligand (S)-4C3HPG protects neurons after global ischaemia in gerbils

The mGlu receptor ligand (S)-4C3HPG protects neurons after global ischaemia in gerbils

  • Neuroreport. 1998 Apr 20;9(6):985-8. doi: 10.1097/00001756-199804200-00006.
P Henrich-Noack 1 C D Hatton K G Reymann
Affiliations

Affiliation

  • 1 Department of Neurophysiology, Federal Institute for Neurobiology, Magdeburg, Germany.
Abstract

(S)-4-Carboxy-3-hydroxy-phenylglycine [(S)-4C3HPG] is a potent competitive antagonist at the metabotropic glutamate receptor 1 subtype (mGlu1 receptor) and an agonist at mGlu2/3 receptor. We evaluated histologically the effect of this compound on transient global ischaemia in gerbils and observed pronounced neuroprotection in the CA1 layer of the hippocampus. When (S)-4C3HPG (1 microM) was administered intra-cerebroventricularly (i.c.v.) 20 min before clamping both common carotid arteries neuronal density was comparable with that in sham-operated Animals. A single injection (1 microM) 65 min after ischaemia also significantly reduced neuronal damage. The results suggest that Metabotropic Glutamate Receptors play a role in the deleterious cascade which leads to neuronal damage of pyramidal cells in the CA1 layer of the hippocampus after transient global ischaemia.

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