2. Academic Validation
  3. Antitumor activity of paclitaxel and epirubicin in human breast carcinoma, R-27

Antitumor activity of paclitaxel and epirubicin in human breast carcinoma, R-27

  • Folia Microbiol (Praha). 1998;43(5):473-4. doi: 10.1007/BF02820793.
F Asanuma 1,  Y Yamada,  E Kawamura,  K Lee,  H Kobayashi,  T Yamada,  T Suzuki,  T Kubota
Affiliations

Affiliation

  • 1 Department of Surgery, Kitasato Institute Hospital, Tokyo, Japan.
PMID: 9821299 DOI: 10.1007/BF02820793
Abstract

The antitumor effect of paclitaxel, epirubicin, and both in combination was tested using R-27, an estrogen receptor-positive human breast carcinoma. In an in vivo study using nude mice both drugs showed an additive effect, whereas they showed a supraadditive pattern in in vitro MTT assay. The combination of paclitaxel and epirubicin may enhance the antitumor effect on breast carcinoma.

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