2. Academic Validation
  3. NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists

NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists

  • Bioorg Med Chem Lett. 1998 Oct 6;8(19):2715-8. doi: 10.1016/s0960-894x(98)00469-7.
J Yuan 1,  X Chen,  R Brodbeck,  R Primus,  J Braun,  J W Wasley,  A Thurkauf
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Neurogen Corporation, Branford, CT 06405, USA.
PMID: 9873609 DOI: 10.1016/s0960-894x(98)00469-7
Abstract

N-(4-[4-¿2, 3-dichlorophenyl¿-1-piperazinyl]butyl)-3-fluorenylcarboxamide and N-(4-[4-¿2, 3-dichlorophenyl¿-1-piperazinyl]butyl)-2-biphenylenylcarboxamide were prepared in several steps from 2,3-dichloroaniline. These compounds were identified as highly selective dopamine D3 receptor antagonists.

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