2. Metabolic Enzyme/Protease
  3. Elastase
  4. MDL 101146

MDL 101146 是一种中性粒细胞弹性蛋白酶抑制剂，具有口服活性。MDL 101146 抑制人类的中性粒细胞弹性蛋白酶，Ki 值为 25 nM。MDL 101146 可用于关节炎的研究。

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MDL 101146 Chemical Structure

MDL 101146 Chemical Structure

CAS No. : 149859-17-6

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MDL 101146 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a Ki value of 25 nM. MDL 101146 can be used for the research of arthritis[1][2].

IC50 & Target

Ki for neutrophil elastase: 25 nM (human); 18 nM (rat)[1][2]
体外研究
(In Vitro)

MDL 101,146 inhibits human neutrophil elastase with a Ki value of 25 nM[1].
MDL 101,146 inhibits rat neutrophil elastase activity in a dose-related manner with a Ki value of 18 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MDL 101146 相关抗体:
体内研究
(In Vivo)

MDL 101146 (oral, 200 mg/kg/day) significantly inhibits swelling and joint destruction in collagen-induced arthritis but not in adjuvant arthritis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[2]
Dosage: 200 mg/kg
Administration: Oral, 200 mg/kg/day
Result: Inhibited the severity of collagen-induced arthritis.
Had a bone and cartilage sparing effect in the tibio-tarsal joint of animals with collagen-induced arthritis.
分子量

632.62

Formula

C29H37F5N4O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MDL 101146 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDL 101146149859-17-6MDL101146MDL-101146Elastaseoralneutrophil elastasearthritiscartilage degradationInhibitorinhibitorinhibit

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