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  4. MDM2/XIAP-IN-1

MDM2/XIAP-IN-1 (compound 14) 是一种具有口服活性MDM2/XIAP 双靶点抑制剂。MDM2/XIAP-IN-1具有抗癌活性，IC50 值为0.3 μM，可用于癌症研究。

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MDM2/XIAP-IN-1 Chemical Structure

MDM2/XIAP-IN-1 Chemical Structure

CAS No. : 359595-95-2

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MDM2/XIAP-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MDM2/XIAP-IN-1 (compound 14) is an orally active inhibitor of dual MDM2/XIAP. MDM2/XIAP-IN-1 has anti-cancer activity with an IC50 value of 0.3 μM, which can be used in cance rescrch[1].

IC50 & Target

IC50:0.3 μM (EU-1 cell)[1]
体外研究
(In Vitro)

MDM2/XIAP-IN-1 (0-4 μM, 2 weeks) 抑制 EU-1、EU-3 和 NB-1643、SHEP 和 LA1-55 的细胞活性[1]。
MDM2/XIAP-IN-1 可降解 MDM2和d XIAP，并靶向杀伤肿瘤细胞，对普通细胞无毒性。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MDM2/XIAP-IN-1 相关抗体:

Clonogenic Assay：

Cell Line: NB and normal human hematopoietic cells[1]
Concentration: 0-4 μM
Incubation Time: 2 weeks
Result: Inhibited tumor cell growth, non-toxic to normal human hematopoietic cells.

Western Blot Analysis

Cell Line: EU-1 cell[1]
Concentration: 0-2 μM
Incubation Time: 0-24 h
Result: Caused the MDM2 and XIAP degradation as well as inducted p53 expression.
体内研究
(In Vivo)


MDM2/XIAP-IN-1 Pharmacokinetic Analysis in Male SD rats Model[1]

药代动力学分析[1]

Route Dose (mg/kg) AUClast (ng·h/mL) t1/2 (h) Clobs (L·h/kg) F (%)
i.v. 10 4750 0.94 2.12 /
p.o. 25 0.71 / / 5.9%

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

488.60

Formula

C28H28N2O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MDM2/XIAP-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDM2/XIAP-IN-1359595-95-2OthersMDM2/XIAP InhibitorInhibitorinhibitorinhibit

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产品名称：
MDM2/XIAP-IN-1
目录号：
HY-153199
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