2. Membrane Transporter/Ion Channel Cytoskeleton Metabolic Enzyme/Protease
  3. Fat Mass and Obesity-associated Protein (FTO) Potassium Channel Gap Junction Protein Endogenous Metabolite
  4. Meclofenamic acid sodium hydrate

Meclofenamic acid sodium hydrate  (Synonyms: Meclofenamate sodium hydrate)

目录号: HY-117275A
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摩尔计算器

Meclofenamic acid (Meclofenamate) sodium hydrate 是一种非甾体抗炎剂。Meclofenamic acid sodium hydrate 是一种高选择性的脂肪和肥胖相关酶 (FTO) 抑制剂。Meclofenamic acid sodium hydrate 与 FTO 竞争，与含有 m(6)A 的核酸结合。Meclofenamic acid sodium hydrate 是一种非选择性的缝隙连接 (gap-junction) 阻滞剂。Meclofenamic acid sodium hydrate 抑制 hKv2.1 和 hKv1.1，其 IC50 分别为 56.0 和 155.9 μM。

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Meclofenamic acid sodium hydrate Chemical Structure

Meclofenamic acid sodium hydrate Chemical Structure

CAS No. : 67254-91-5

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Meclofenamic acid sodium hydrate 的其他形式现货产品:

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Meclofenamic acid sodium hydrate 相关抗体

Top Publications Citing Use of Products

    Meclofenamic acid sodium hydrate purchased from MCE. Usage Cited in: Theranostics. 2021 Jul 25;11(17):8464-8479.  [Abstract]

    The effect of FTO inhibitor Meclofenamate sodium (MS) (80 μM and 120 μM) on ATF4 protein expression and mTORC1 activity during 968 treatment is detected by western blotting. MS efficiently reduces ATF4 expression and rescues the mTOR downregulation induced by compound 968.

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    • 参考文献

    生物活性

    Meclofenamic acid (Meclofenamate) sodium hydrate is a non-steroidal anti-inflammatory agent. Meclofenamic acid sodium hydrate is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid sodium hydrate competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid sodium hydrate is a non-selective gap-junction blocker. Meclofenamic acid sodium hydrate inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively[1][2][3][4].

    IC50 & Target

    IC50: 1 μM (cyclooxygenase), 56.0 μM (hKv2.1), 155.9 μM (hKv1.1)[3]
    体外研究
    (In Vitro)

    Meclofenamic acid sodium hydrate (0-100 μM, 24 h) inhibits FTO demethylation in a dose-response manner[1].
    Meclofenamic acid sodium hydrate inhibits enzyme cyclooxygenase, with an IC50 about 1 μM, thereby inhibiting the production of prostaglandins[2].
    Meclofenamic acid sodium hydrate inhibits the release of 5-HETE and LTB4 from human neutrophils stimulated with calcium ionophore and antagonizes the response of tissues to certain prostaglandins[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Meclofenamic acid sodium hydrate 相关抗体:

    Western Blot Analysis[1]

    Cell Line: HeLa cells
    Concentration: 0, 12.5, 25, 50, 100 μM
    Incubation Time: 24 h
    Result: Inhibited FTO demethylation in a dose-response manner, and elevates the levels of cellular m6A in mRNA by targeting FTO.
    Clinical Trial
    分子量

    336.15

    Formula

    C14H12Cl2NNaO3
    CAS 号
    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Meclofenamic acid sodium hydrate 相关分类

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Meclofenamic acid sodium67254-91-5Meclofenamate sodiumFat Mass and Obesity-associated Protein (FTO)Potassium ChannelGap Junction ProteinEndogenous MetaboliteKcsAneuronalpotassium channelK+ channelvoltage-gatedhKv2.1anti-inflammatoryRGCsgap junctionInhibitorinhibitorinhibit

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    目录号：
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