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  4. Meglumine (Excipient)

Meglumine (Excipient)  (Synonyms: Methylglucamine (Excipient); Meglumin (Excipient); Methylglucamin (Excipient))

目录号: HY-B0342A
产品使用指南

摩尔计算器

Meglumine (Methylglucamine) (Excipient) 是一种具有口服活性的源自山梨糖醇的氨基糖。Meglumine (Excipient) 有抗炎和抗肿瘤活性。Meglumine (Excipient) 常在活性分子中用作赋形剂，并与碘代化合物葡甲胺和碘帕胺葡甲胺等造影剂中的碘化化合物一起使用。

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Meglumine (Excipient) Chemical Structure

Meglumine (Excipient) Chemical Structure

CAS No. : 6284-40-8

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Meglumine (Excipient) 的其他形式现货产品:

Other Forms of Meglumine (Excipient):

Meglumine (Excipient) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Meglumine (Methylglucamine) (Excipient) is an orally active amino sugar derived from sorbitol. Meglumine (Excipient) has anti-inflammatory and antitumor activity. Meglumine (Excipient) is often used as an excipient in active molecules and with iodinated compounds in contrast agents such as meglumine and meglumine iodide[1][2][3].

体外研究
(In Vitro)

Meglumine (Excipient) (40 或 80 mM，24 h；50 mM, 24 h) 在 THP-1 人髓样细胞和 RAW264.7 小鼠巨噬细胞细胞中剂量依赖性降低炎症因子水平 (Elisa assay)[2]。
Meglumine (Excipient) (0-300 mM, 60 min) 在 C2C12 小鼠成肌细胞中剂量依赖性的增加 SNARK 的表达水平[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Meglumine (Excipient) 相关抗体:

Western Blot Analysis[4]

Cell Line: C2C12 mouse myoblasts
Concentration: 0, 10, 30, 100, 300 mM or 200 mM
Incubation Time: 60 min or 0, 10, 30, 60, 120 min
Result: Increased the levels of SNARK protein in a dose-dependent manner after 60 min and reached a plateau at 30 minutes.
体内研究
(In Vivo)

Meglumine (Excipient) (25 或 50 mM；37.5 mM, 溶解在水中口服) 在大鼠和小鼠中可减少炎症因子水平，抑制皮肤癌肿瘤生长[2]。
Meglumine (Excipient) (18 mM, 口服) 在 Ⅱ 型糖尿病小鼠中可改善肌肉功能、限制代谢综合征和减少糖尿病并发症[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rat[2]
Dosage: 25 or 50 mM
Administration: p.o., dissolve in water
Result: Reduced the isoprostane levels in rats.
Animal Model: K6/ODC transgenic mice[2]
Dosage: 37.5 mM
Administration: p.o., dissolve in water
Result: Reduced the number of skin tumors and inhibited tumor growth.
Animal Model: KK.Cg-Ay/J mice[4]
Dosage: 18 mM
Administration: p.o., dissolve in water
Result: Performed better in a glucose tolerance test.
Decreased their average fasting levels of glucose and triglyceride levels in both the liver and blood serum.
分子量

195.21

Formula

C7H17NO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Meglumine (Excipient) 相关分类

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Meglumine (Excipient)6284-40-8Methylglucamine (Excipient) Meglumin (Excipient) Methylglucamin (Excipient)Biochemical Assay ReagentsTHP-1RAW264.7K6/ODC transgenic miceAnti-inflammatoryInhibitorinhibitorinhibit

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