2. Epigenetics Membrane Transporter/Ion Channel
  3. Epigenetic Reader Domain Potassium Channel
  4. Menin–KMT2A-IN-1

Menin–KMT2A-IN-1 (Compound 20) 是 menin–KMT2A 的抑制剂，可与 menin 结合（IC50 为 8 nM），并抑制 menin 与赖氨酸甲基转移酶 2A (KMT2A) 之间的相互作用。Menin–KMT2A-IN-1 可抑制 hERG，IC50 为 65 μM。Menin–KMT2A-IN-1 可抑制细胞 MV4-11，IC50 为 74 nM。Menin–KMT2A-IN-1 在 CD-1 小鼠中表现出良好的药代动力学特性，口服生物利用度为 74%。i

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Menin–KMT2A-IN-1 Chemical Structure

Menin–KMT2A-IN-1 Chemical Structure

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Menin–KMT2A-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Menin–KMT2A-IN-1 (Compound 20) is the inhibitor for menin–KMT2A that binds to menin with an IC50 of 8 nM, and inhibits the interaction between menin and lysine methyltransferase 2A (KMT2A). Menin–KMT2A-IN-1 inhibits hERG with an IC50 of 65 μM. Menin–KMT2A-IN-1 inhibits cell MV4-11 with an IC50 of 74 nM. Menin–KMT2A-IN-1 exhibits good pharmacokinetic characteristics in CD-1 mouse with an orally bioavailability of 74%[1].

分子量

522.61

Formula

C28H35FN6O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Menin–KMT2A-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Menin–KMT2A-IN-1Epigenetic Reader DomainPotassium ChannelKcsAMV4-11CD-1 mouseleukemiaInhibitorinhibitorinhibit

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