Mercaptoethylguanidine (MEG) (dihydrobromide)  (Synonyms: 巯基乙基胍(MEG)二氢溴化物)

Mercaptoethylguanidine (MEG) dihydrobromide is selective inhibitor of the inducible nitric oxide synthase and peroxynitrite scavenger. Mercaptoethylguanidine (MEG) dihydrobromide has the potential for inflammatory bowel diseases research.

Mercaptoethylguanidine (MEG; 10 mg/kg i.v. b. i.d.) dihydrobromide significantly reduces the appearance of diarrhea and the loss of body weight in male rats with colitis^[1].
Mercaptoethylguanidine (10 mg/kg/day; ip; for 5 days) dihydrobromide ameliorates oxidative stress parameters and antioxidant enzyme activities in forty-five Sprague-Dawley rats weighing 200 to 250 g with esophagus uninjured^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

281.01

C₃H₁₁Br₂N₃S

32665-11-5

巯基乙基胍(MEG)二氢溴化物

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. B Zingarelli, et al. Mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, reduces trinitrobenzene sulfonic acid-induced colonic damage in rats. J Pharmacol Exp Ther. 1998 Dec;287(3):1048-55.  [Content Brief]

  [2]. Ahmet Guven, et al. Mercaptoethylguanidine attenuates caustic esophageal injury in rats: a role for scavenging of peroxynitrite. J Pediatr Surg. 2011 Sep;46(9):1746-52.  [Content Brief]