2. Anti-infection
  3. Beta-lactamase
  4. Metallo-β-lactamase-IN-15

Metallo-β-lactamase-IN-15 (Compound ±13) 是一种有效的 MBL 抑制剂，对NDM-1，IMP-1 和 VIM-2 的 IC50 值分别为 0.29 μM，0.088 μM和 0.063 μM

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Metallo-β-lactamase-IN-15 Chemical Structure

Metallo-β-lactamase-IN-15 Chemical Structure

CAS No. : 1804934-57-3

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Metallo-β-lactamase-IN-15 相关抗体

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Metallo-β-lactamase

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Metallo-β-lactamase-IN-15 (Compound ±13) is a potent MBL inhibitor, the IC50 values for NDM-1、IMP-1 and VIM-2 were 0.29 μM, 0.088 μM and 0.063 μM, respectively[1].

IC50 & Target

NDM-1

0.29 μM (IC50)

VIM-2

0.063 μM (IC50)

IMP-1

0.088 μM (IC50)

体外研究
(In Vitro)

Metallo-β-lactamase-IN-15 (Compound ±13) (50 μg/mL; 100 μg/mL) 对 L929 细胞无毒性[1]。
Metallo-β-lactamase-IN-15 具有良好的生物利用度和血浆稳定性[1]。
Metallo-β-lactamase-IN-15 (100 μg/mL；1、3、5h）对表达 NDM-1 的大肠杆菌 DH5α 菌株生长的活性测试，Metallo-β-lactamase-IN-15 恢复了亚胺培南的体外活性[1]。
Metallo-β-lactamase-IN-15 (100 μg/mL) 能降低临床大肠杆菌 DH5α 菌株的美罗培南的最低抑制浓度[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Metallo-β-lactamase-IN-15 相关抗体:

Cell Line:
Concentration:
Incubation Time:
Result:

Cell Line:
Concentration:
Incubation Time:
Result:

Cell Viability Assay

Cell Line: E.coli DH5α cells
Concentration: 100 ug/mL
Incubation Time: 1h, 3h, 5h
Result: Metallo-β-lactamase-IN-15 restored imipenem activity[1].

Cell Line:
Concentration:
Incubation Time:
Result:

Cell Line:
Concentration:
Incubation Time:
Result:
分子量

241.40

Formula

C10H11NS3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Metallo-β-lactamase-IN-15 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Metallo-β-lactamase-IN-151804934-57-3Beta-lactamaseβ-lactamaseAntimicrobial resistanceMBL inhibitorsBBH inhibitors.Inhibitorinhibitorinhibit

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