Methyl brevifolincarboxylate  (Synonyms: Brevifolincarboxylic acid methyl ester)

Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor. Methyl brevifolincarboxylate has anti-oxidant activity. Methyl brevifolincarboxylate also inhibits platelet aggregation, lipid metabolism and inflammation^{[1][2][4][5][6]}.

Methyl brevifolincarboxylate 具有显着的 DPPH 自由基清除活性，IC₅₀ 值为 8.9 μM^[2]。
Methyl brevifolincarboxylate (10 和 30 μM) 抑制 LPS 刺激的巨噬细胞中 NO 和 TNF-α 的产生^[2]。
Methyl brevifolincarboxylate (1 和 10 μM) 抑制去甲肾上腺素 (Norepinephrine (HY-13715)) 诱导的大鼠主动脉收缩^[3]。
Methyl brevifolincarboxylate (5 μM) 抑制血小板聚集达 73.5%^[4]。
Methyl brevifolincarboxylate 对流感病毒 A/Puerto Rico/8/34 (H1N1) 和 A/Aichi/2/68 (H3N2) 有抑制作用，IC₅₀ 分别为 27.16 μM 和 33.41 μM^[5]。
Methyl brevifolincarboxylate (10-80 μM，48 小时) 降低 OA 处理的 SK-HEP-1 细胞和原代小鼠肝细胞中的 TG 水平^[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

306.22

C₁₄H₁₀O₈

154702-76-8

短叶苏木酚酸甲酯

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wu QY, et al. Chromatographic fingerprint and the simultaneous determination of five bioactive components of geranium carolinianum L. water extract by high performance liquid chromatography. Int J Mol Sci. 2011;12(12):8740-8749.  [Content Brief]

  [2]. Fang SH, et al. Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria. J Ethnopharmacol. 2008;116(2):333-340.  [Content Brief]

  [3]. Iizuka T, et al. Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri. Biol Pharm Bull. 2006 Jan;29(1):177-9.  [Content Brief]

  [4]. Iizuka T, et al. Inhibitory effects of methyl brevifolincarboxylate isolated from Phyllanthus niruri L. on platelet aggregation. Biol Pharm Bull. 2007 Feb;30(2):382-4.  [Content Brief]