2. Anti-infection
  3. Influenza Virus
  4. Methyl brevifolincarboxylate

Methyl brevifolincarboxylate  (Synonyms: Brevifolincarboxylic acid methyl ester)

目录号: HY-N7647
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Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) 是一种有效的流感病毒 PB2 帽结合抑制剂。Methyl brevifolincarboxylate 具有抗氧化活性。Methyl brevifolincarboxylate 还抑制血小板聚集、脂质代谢和炎症。

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Methyl brevifolincarboxylate Chemical Structure

Methyl brevifolincarboxylate Chemical Structure

CAS No. : 154702-76-8

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Methyl brevifolincarboxylate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor. Methyl brevifolincarboxylate has anti-oxidant activity. Methyl brevifolincarboxylate also inhibits platelet aggregation, lipid metabolism and inflammation[1][2][4][5][6].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Erythrocyte IC50
1.04 mM
Compound: 13
Anticomplement activity in sheep erythrocytes assessed as concentration required for 50% hemolytic inhibition by classic pathway pretreated for 10 mins with guinea pig serum followed by erythrocyte addition measured after 30 mins by spectrophotometeric me
Anticomplement activity in sheep erythrocytes assessed as concentration required for 50% hemolytic inhibition by classic pathway pretreated for 10 mins with guinea pig serum followed by erythrocyte addition measured after 30 mins by spectrophotometeric me
[PMID: 29631958]
Erythrocyte IC50
1.26 mM
Compound: 13
Anticomplement activity in rabbit erythrocytes assessed as concentration required for 50% hemolytic inhibition by alternative pathway pretreated for 10 mins with normal human serum followed by erythrocyte addition measured after 30 mins by spectrophotomet
Anticomplement activity in rabbit erythrocytes assessed as concentration required for 50% hemolytic inhibition by alternative pathway pretreated for 10 mins with normal human serum followed by erythrocyte addition measured after 30 mins by spectrophotomet
[PMID: 29631958]
体外研究
(In Vitro)

Methyl brevifolincarboxylate 具有显着的 DPPH 自由基清除活性，IC50 值为 8.9 μM[2]。
Methyl brevifolincarboxylate (10 和 30 μM) 抑制 LPS 刺激的巨噬细胞中 NO 和 TNF-α 的产生[2]。
Methyl brevifolincarboxylate (1 和 10 μM) 抑制去甲肾上腺素 (Norepinephrine (HY-13715)) 诱导的大鼠主动脉收缩[3]。
Methyl brevifolincarboxylate (5 μM) 抑制血小板聚集达 73.5%[4]。
Methyl brevifolincarboxylate 对流感病毒 A/Puerto Rico/8/34 (H1N1) 和 A/Aichi/2/68 (H3N2) 有抑制作用，IC50 分别为 27.16 μM 和 33.41 μM[5]。
Methyl brevifolincarboxylate (10-80 μM，48 小时) 降低 OA 处理的 SK-HEP-1 细胞和原代小鼠肝细胞中的 TG 水平[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Methyl brevifolincarboxylate 相关抗体:

Cell Viability Assay[6]

Cell Line: SK-HEP-1 cells
Concentration: 10, 20, 40, 80 μM
Incubation Time: 48 h
Result: Reduced the protein levels of FASN, SREBP-1c and ACC1.
Increased the expression of PPAR-α.
分子量

306.22

Formula

C14H10O8
CAS 号
中文名称

短叶苏木酚酸甲酯
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Methyl brevifolincarboxylate 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methyl brevifolincarboxylate154702-76-8Brevifolincarboxylic acid methyl ester短叶苏木酚酸甲酯Influenza VirusMacrophageLPSDPPHNOplateletrat aortaNorepinephrineInhibitorinhibitorinhibit

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