2. Immunology/Inflammation
  3. NO Synthase
  4. Methyl-L-NIO hydrochloride

Methyl-L-NIO (compound 2d) hydrochloride 是潜在的二甲基精氨酸二甲氨基水解酶 hDDAH 的选择性抑制剂 (IC50: 70 μM)。Methyl-L-NIO 对 NO 合成酶也具有抑制活性。Methyl-L-NIO 在 100 μM 浓度下对 NO 合成酶不同亚型的抑制率分别为 77% (nNOS)，20% (eNOS)，72% (iNOS)；在 1 mM 浓度下的抑制率分别为 100% (nNOS)，85% (eNOS)，100% (iNOS)。

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Methyl-L-NIO hydrochloride Chemical Structure

Methyl-L-NIO hydrochloride Chemical Structure

CAS No. : 150403-96-6

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Methyl-L-NIO hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 NO Synthase 亚型特异性产品:

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nNOS iNOS eNOS

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Methyl-L-NIO (compound 2d) hydrochloride is a potential selective inhibitor (IC50: 70 μM) of dimethylarginine dimethylaminohydrolase hDDAH. Methyl-L-NIO also has inhibitory activity against NO synthase. The inhibition rates of Methyl-L-NIO on different isoforms of NO synthase at a concentration of 100 μM are 77% (nNOS), 20% (eNOS), and 72% (iNOS) respectively; the inhibition rates at a concentration of 1 mM are 100% (nNOS), 85% (eNOS), 100% (iNOS)[1].

IC50 & Target

IC50: 70 μM (hDDAH, Dimethylarginine dimethylaminohydrolase)[1]
分子量

223.70

Formula

C8H18ClN3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Methyl-L-NIO hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Methyl-L-NIO150403-96-6NO SynthaseNitric oxide synthasesNOSInhibitorinhibitorinhibit

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产品名称：
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HY-139135
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