2. Immunology/Inflammation Apoptosis
  3. CD38 Apoptosis
  4. Mezagitamab

Mezagitamab  (Synonyms: 迈泽妥单抗; TAK-079)

目录号: HY-P99730 纯度: 99.76%
COA 技术支持

Mezagitamab (TAK-079) 是一种 IgG1λ 抗 CD38 的单克隆抗体。Mezagitamab 通过抗体和补体依赖性细胞毒性耗尽表达 CD38 的肿瘤细胞。Mezagitamab 在复发/难治性多发性骨髓瘤 (RRMM) 和原发性血小板减少性紫癜 (ITP) 中有潜在应用。

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CAS No. : 2227490-52-8

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规格 价格 是否有货 数量
1 mg ￥3000
In-stock
5 mg ￥7800
In-stock
10 mg   询价  
50 mg   询价  

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Customer Review

Mezagitamab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mezagitamab (TAK-079) is a IgG1λ anti-CD38 monoclonal antibody. Mezagitamab depletes tumor cells expressing CD38 through antibody and complement dependent cytotoxicity. Mezagitamab has potential application in relapsed/refractory multiple myeloma (RRMM) and idiopathic thrombocytopenic purpura (ITP)[1][2][3].

同型

Human IgG1 lambda1
推荐同型对照抗体
种属

Humanized
体外研究
(In Vitro)

Mezagitamab 与 CD38 结合，变构抑制 CD38 酶的活性，通过抗体依赖性细胞毒性 (ADCC，激活 NK 细胞等免疫细胞) 和补体依赖性细胞毒性 (CDC，激活补体系统) 诱导细胞凋亡 (apoptosis)[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mezagitamab 相关抗体:
体内研究
(In Vivo)

Mezagitamab (0.03-100 mg/kg, iv, once or twice a week for 4-13 weeks) 在食蟹猴模型中诱导 NK 细胞、B 细胞和 T 细胞耗竭[4]。
Mezagitamab (3 mg/kg, iv,once weekly for 8 weeks) 可在食蟹猴模型中预防胶原诱导性的关节炎[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkey models[4]
Dosage: 0.03-100 mg/kg
Administration: iv, once or twice a week for 4-13 weeks
Result: Reduced numbers of NK/B/T cells.
Animal Model: Collagen-induced arthritis in cynomolgus monkey models[4]
Dosage: 3 mg/kg
Administration: iv,once weekly for 8 weeks
Result: Inhibited the progression of arthritis.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

迈泽妥单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda
Biological Activity
  • Immobilized CD38 Protein, Human can bind Mezagitamab. The EC50 for this effect is 61.97 ng/mL.
纯度 & 产品资料
参考文献

Mezagitamab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mezagitamab2227490-52-8TAK-079迈泽妥单抗TAK079TAK 079CD38ApoptosisRRMMITPInhibitorinhibitorinhibit

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