2. Apoptosis
  3. MDM-2/p53
  4. MI 63

MI 63 通过靶向 MDM2， 可以激活 p53 (Ki 为 3 nM)。MI 63 可抑制胚胎和肺泡横纹肌肉瘤细胞 (ERMS 和 ARMS) 的增殖 (RH36 细胞中的 IC50 为 0.58 μM)，并诱导 ERMS，ARMS 细胞凋亡 (apoptosis)。

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MI 63 Chemical Structure

MI 63 Chemical Structure

CAS No. : 908027-21-4

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MI 63 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MI 63 is an activator for p53, by targeting the MDM2 (Ki is 3 nM). MI 63 inhibits the proliferation of embryonic and alveolar rhabdomyosarcoma (ERMS and ARMS) cells (IC50 is 0.58 μM in RH36 cells), and induces apoptosis in ERMS and ARMS[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A2780 GI50
1.19 μM
Compound: 2a, MI-63
Growth inhibition of human A2780 cells expressing MDM2 by SRB assay
Growth inhibition of human A2780 cells expressing MDM2 by SRB assay
[PMID: 21875801]
HCT-116 IC50
0.7 μM
Compound: 1, MI-63
Growth inhibition of human HCT116 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay
Growth inhibition of human HCT116 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay
[PMID: 19928922]
HCT-116 GI50
1.3 μM
Compound: 2a, MI-63
Growth inhibition of human HCT116 cells expressing MDM2 by SRB assay
Growth inhibition of human HCT116 cells expressing MDM2 by SRB assay
[PMID: 21875801]
HCT-116 GI50
11.8 μM
Compound: 2a, MI-63
Growth inhibition of p53 deficient human HCT116 cells expressing MDM2 by SRB assay
Growth inhibition of p53 deficient human HCT116 cells expressing MDM2 by SRB assay
[PMID: 21875801]
HCT-116 IC50
14.4 μM
Compound: 1, MI-63
Growth inhibition of human HCT116 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay
Growth inhibition of human HCT116 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay
[PMID: 19928922]
SAOS-2 IC50
14.1 μM
Compound: 1, MI-63
Growth inhibition of human Saos2 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay
Growth inhibition of human Saos2 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay
[PMID: 19928922]
SJSA-1 IC50
0.5 μM
Compound: 1, MI-63
Growth inhibition of human SJSA1 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay
Growth inhibition of human SJSA1 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay
[PMID: 19928922]
SJSA-1 GI50
0.55 μM
Compound: 2a, MI-63
Growth inhibition of human SJSA1 cells expressing MDM2 by SRB assay
Growth inhibition of human SJSA1 cells expressing MDM2 by SRB assay
[PMID: 21875801]
分子量

577.52

Formula

C29H35Cl2FN4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MI 63 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MI 63908027-21-4MI63MI-63MDM-2/p53RH36RH18RH30HCT116rhabdomyosarcomaRMSERMSARMSInhibitorinhibitorinhibit

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