Microtubule destabilizing agent-1

目录号: HY-139981: FAQs
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摩尔计算器

Microtubule destabilizing agent-1 (Compound 12b) 是一种基于异羟肟酸的微管去稳定剂 (MDA)。Microtubule destabilizing agent-1 显示出良好的代谢稳定性、高生物利用度和有效的抗肿瘤活性。

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Microtubule destabilizing agent-1 Chemical Structure

CAS No. : 2850370-28-2

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生物活性
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参考文献

生物活性

Microtubule destabilizing agent-1 (Compound 12b) acts as a microtubule destabilizing agent (MDA) based on hydroxamic acid, could serve as a potential MDA for further investigation. Microtubule destabilizing agent-1 shows favorable metabolism stability, high bioavailability, and potent antitumor activity^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
786-0	IC₅₀	3.53 nM Compound: 12b	Antiproliferative activity against human 786-O cells incubated for 72 hrs by MTT assay Antiproliferative activity against human 786-O cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
A2780/Taxol	IC₅₀	6.27 nM Compound: 12b	Antiproliferative activity against human A2780T cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A2780T cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
A2780S	IC₅₀	1.85 nM Compound: 12b	Antiproliferative activity against human A2780S cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A2780S cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
A549	IC₅₀	2.76 nM Compound: 12b	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
A549/TR	IC₅₀	3.12 nM Compound: 12b	Antiproliferative activity against human A549/T cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549/T cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
HCT-116	IC₅₀	1.37 nM Compound: 12b	Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
HeLa	IC₅₀	3.15 nM Compound: 12b	Antiproliferative activity against human HeLa cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HeLa cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
HepG2	IC₅₀	1.6 nM Compound: 12b	Antiproliferative activity against human HepG2 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
HT-29	IC₅₀	3.78 nM Compound: 12b	Antiproliferative activity against human HT-29 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
Huh-7	IC₅₀	2.19 nM Compound: 12b	Antiproliferative activity against human Huh-7 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human Huh-7 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
MCF7	IC₅₀	6.06 nM Compound: 12b	Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
MDA-MB-231	IC₅₀	2.02 nM Compound: 12b	Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
MOLM-13	IC₅₀	9.85 nM Compound: 12b	Antiproliferative activity against human MOLM-13 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MOLM-13 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
MV4-11	IC₅₀	2.17 nM Compound: 12b	Antiproliferative activity against human MV4-11 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MV4-11 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
NCI-H460	IC₅₀	5.6 nM Compound: 12b	Antiproliferative activity against human NCI-H460 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
Ramos	IC₅₀	3.62 nM Compound: 12b	Antiproliferative activity against human Ramos cells incubated for 72 hrs by MTT assay Antiproliferative activity against human Ramos cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
THP-1	IC₅₀	3.83 nM Compound: 12b	Antiproliferative activity against human THP-1 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human THP-1 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]

分子量

410.47

Formula

C₂₂H₂₆N₄O₄

CAS 号

2850370-28-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Linyu Yang, et al. Discovery of a Series of Hydroxamic Acid-Based Microtubule Destabilizing Agents with Potent Antitumor Activity. J Med Chem. 2021 Oct 28;64(20):15379-15401. [Content Brief]

Microtubule destabilizing agent-1 相关分类

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稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Microtubule destabilizing agent-12850370-28-2Microtubule destabilizing agent1Microtubule destabilizing agent 1Microtubule/Tubulinmicrotubule destabilizing agentMDAmetabolism stabilityhigh bioavailabilityantitumorInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

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Microtubule destabilizing agent-1

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Microtubule destabilizing agent-1 相关分类

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