2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Microtubule inhibitor 1

Microtubule inhibitor 1 是一种抗癌活性分子，能够抑制微管聚合，其在肿瘤细胞中的IC50 为 9-16 nM。

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Microtubule inhibitor 1 Chemical Structure

Microtubule inhibitor 1 Chemical Structure

CAS No. : 2305668-80-6

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Microtubule inhibitor 1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Microtubule inhibitor 1 is an antitumor agent with microtubule polymerization inhibitory activity, with an IC50 value of 9-16 nM in cancer cells[1].

IC50 & Target

Microtubule polymerization[1].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-8 IC50
0.015 μM
Compound: 24d
Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay
[PMID: 30525584]
HepG2 IC50
0.015 μM
Compound: 24d
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
[PMID: 30525584]
HUVEC IC50
0.25 μM
Compound: 24d
Antiproliferative activity against human HUVEC cells after 24 hrs by MTT assay
Antiproliferative activity against human HUVEC cells after 24 hrs by MTT assay
[PMID: 30525584]
K562 IC50
0.009 μM
Compound: 24d
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
[PMID: 30525584]
KB IC50
0.016 μM
Compound: 24d
Antiproliferative activity against human KB cells after 72 hrs by MTT assay
Antiproliferative activity against human KB cells after 72 hrs by MTT assay
[PMID: 30525584]
L02 IC50
0.987 μM
Compound: 24d
Cytotoxicity against human LO2 cells after 72 hrs by MTT assay
Cytotoxicity against human LO2 cells after 72 hrs by MTT assay
[PMID: 30525584]
MDA-MB-231 IC50
0.015 μM
Compound: 24d
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 30525584]
分子量

333.38

Formula

C21H19NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Microtubule inhibitor 1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Microtubule inhibitor 12305668-80-6Microtubule inhibitor1Microtubule inhibitor-1Microtubule/TubulinInhibitorinhibitorinhibit

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目录号：
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