2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Microtubule inhibitor 3

化合物17o（IC50= 14.0 nM，NCI-H460）和17p（IC50= 2.9 nM，NCI-H460）与呋喃基团在纳摩尔水平上对各种人类癌细胞系表现出有效的细胞毒性活性。

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Microtubule inhibitor 3 Chemical Structure

Microtubule inhibitor 3 Chemical Structure

CAS No. : 1236141-96-0

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Microtubule inhibitor 3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Compounds 17O (ic50= 14.0 nm, NCI-H460) and 17p (ic50= 2.9 nm, NCI-H460) and furan groups showed effective cytotoxic activity against various human cancer cell lines at the nanomolar level.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.8 nM
Compound: 16j
Cytotoxicity against human A549 cells after 48 hrs by WST-8 assay
Cytotoxicity against human A549 cells after 48 hrs by WST-8 assay
[PMID: 22727370]
BXPC-3 IC50
0.6 nM
Compound: 1
Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 32278711]
HeLa IC50
1.7 nM
Compound: 16j
Cytotoxicity against human HeLa cells after 48 hrs by WST-8 assay
Cytotoxicity against human HeLa cells after 48 hrs by WST-8 assay
[PMID: 22727370]
HT-29 IC50
0.5 nM
Compound: 16j
Cytotoxicity against human HT-29 cells after 48 hrs by XTT assay
Cytotoxicity against human HT-29 cells after 48 hrs by XTT assay
[PMID: 22727370]
HT-29 IC50
0.6 nM
Compound: 1
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32278711]
NCI-H460 IC50
3.8 nM
Compound: 1
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32278711]
NCI-H460 IC50
3.8 nM
Compound: 6b
Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by SRB assay
Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by SRB assay
[PMID: 31759826]
分子量

458.48

Formula

C26H23FN4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Microtubule inhibitor 3 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Microtubule inhibitor 31236141-96-0Microtubule inhibitor3Microtubule inhibitor-3Microtubule/TubulinInhibitorinhibitorinhibit

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