2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Microtubule inhibitor 4

Microtubule inhibitor 4 (compound 2) 是一种有效的 microtubule 抑制剂。Microtubule inhibitor 4 对 NCI-H460、BxPC-3、HT-29 细胞具有细胞毒性，IC50s 分别为 4.0、3.2、2.1 nM。Microtubule inhibitor 4 显示对微管蛋白聚合的抑制作用。

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Microtubule inhibitor 4 Chemical Structure

Microtubule inhibitor 4 Chemical Structure

CAS No. : 2411962-64-4

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Microtubule inhibitor 4 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Microtubule inhibitor 4 (compound 2) is a potent microtubule inhibitor. Microtubule inhibitor 4 shows cytotoxicity with IC50s of 4.0, 3.2, 2.1 nM for NCI-H460, BxPC-3, HT-29 cells, respectively. Microtubule inhibitor 4 shows the inhibition of tubulin polymerization[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BXPC-3 IC50
3.2 nM
Compound: 2
Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 32278711]
HCT-116 IC50
3.8 nM
Compound: 6o
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by SRB assay
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by SRB assay
[PMID: 31759826]
HeLa IC50
8.4 nM
Compound: 6o
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by SRB assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by SRB assay
[PMID: 31759826]
HepG2 IC50
3 nM
Compound: 6o
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by SRB assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by SRB assay
[PMID: 31759826]
HT-29 IC50
2.1 nM
Compound: 2
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32278711]
MCF7 IC50
9 nM
Compound: 6o
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by SRB assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by SRB assay
[PMID: 31759826]
NCI-H460 IC50
4 nM
Compound: 2
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32278711]
NCI-H460 IC50
4 nM
Compound: 6o
Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by SRB assay
Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by SRB assay
[PMID: 31759826]
分子量

446.47

Formula

C25H23FN4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Microtubule inhibitor 4 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Microtubule inhibitor 42411962-64-4Microtubule inhibitor4Microtubule inhibitor-4Microtubule/Tubulintubulin polymerizationNCI-H460BxPC-3HT-29cytotoxicityantiproliferativeanticancerInhibitorinhibitorinhibit

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