2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Microtubule inhibitor 6

Microtubule inhibitor 6 (compound 17o) 是一种有效的 微管 抑制剂。Microtubule inhibitor 6 对 NCI-H460、BxPC-3、HT-29 细胞具有细胞毒性，IC50s 分别为 14.0、6.6、7.0 nM。Microtubule inhibitor 6 可有效抑制微管聚合。

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Microtubule inhibitor 6 Chemical Structure

Microtubule inhibitor 6 Chemical Structure

CAS No. : 2416338-64-0

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Microtubule inhibitor 6 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Microtubule inhibitor 6 (compound 17o) is a potent microtubule inhibitor. Microtubule inhibitor 6 shows cytotoxicity with IC50s of 14.0, 6.6, 7.0 nM for NCI-H460, BxPC-3, HT-29 cells, respectively. Microtubule inhibitor 6 efficiently inhibits microtubule polymerization[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BXPC-3 IC50
6.6 nM
Compound: 17o
Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 32278711]
HT-29 IC50
7 nM
Compound: 17o
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32278711]
NCI-H460 IC50
14 nM
Compound: 17o
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32278711]
分子量

434.42

Formula

C24H19FN2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Microtubule inhibitor 6 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Microtubule inhibitor 62416338-64-0Microtubule inhibitor6Microtubule inhibitor-6Microtubule/Tubulintubulin polymerizationNCI-H460BxPC-3HT-29cytotoxicityantiproliferative， anticancerInhibitorinhibitorinhibit

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