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  4. (-)-Cleistenolide

(-)-Cleistenolide  (Synonyms: Cleistenolide)

目录号: HY-N10391
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(-)-Cleistenolide 是一种 α,β- 不饱和 δ- 内酯，从Cleistochlamys kirkii Oliver 中分离得到。(-)-Cleistenolide 具有抗菌和抗肿瘤活性。

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(-)-Cleistenolide Chemical Structure

(-)-Cleistenolide Chemical Structure

CAS No. : 1003600-48-3

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(-)-Cleistenolide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(-)-Cleistenolide is a α,β-unsaturated δ-lactone isolated from Cleistochlamys kirkii Oliver. (-)-Cleistenolide has antibacterial and antitumor activity[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
16.34 μM
Compound: 1
Cytotoxicity against human A549 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 27231128]
HeLa IC50
7.32 μM
Compound: 1
Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 27231128]
HL-60 IC50
1.21 μM
Compound: 1
Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 27231128]
Jurkat IC50
14.22 μM
Compound: 1
Cytotoxicity against human Jurkat cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human Jurkat cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 27231128]
K562 IC50
7.65 μM
Compound: 1
Cytotoxicity against human K562 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human K562 cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 27231128]
MCF7 IC50
26.07 μM
Compound: 1
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 27231128]
MDA-MB-231 IC50
2.25 μM
Compound: 1
Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 27231128]
MRC5 IC50
> 100 μM
Compound: 1
Cytotoxicity against human MRC5 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human MRC5 cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 27231128]
Raji IC50
36.94 μM
Compound: 1
Cytotoxicity against human Raji cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human Raji cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 27231128]
体外研究
(In Vitro)

(-)-Cleistenolide (compound 1) exhibits potent cytotoxicity against cancer cell lines and low cytotoxicity in normal cells MRC-5[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(-)-Cleistenolide 相关抗体:

Cell Cytotoxicity Assay

Cell Line: K562, HL-60, Jurkat, Raji, MCF-7, MDA-MB 231, HeLa, A549 and MRC-5[1]
Concentration: 0-100 μM
Incubation Time:
Result: Exhibited potent cytotoxicity against cancer cell lines with IC50s of 7.65 μM, 1.21 μM, 14.22 μM, 36.94 μM, 26.07 μM, 2.25 μM, 7.32 μM and 16.34 μM in K562, HL-60, Jurkat, Raji, MCF-7, MDA-MB 231, HeLa and A549, respectively; and had low cytotoxicity in normal cells MRC-5 with an IC50 over 100 μM.
分子量

362.33

Formula

C18H18O8
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(-)-Cleistenolide 相关分类

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质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Cleistenolide1003600-48-3CleistenolideBacterialAntibacteriaAntitumorCleistochlamys kirkiiMDA-MB 231HeLaA549Inhibitorinhibitorinhibit

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