2. Anti-infection
  3. Parasite
  4. (-)-Halofantrine

(-)-Halofantrine  (Synonyms: (-)-SKF-102886 free base; (-)-WR-171669)

目录号: HY-A0148B
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摩尔计算器

(-)-Halofantrine ((-)-SKF-102886 free base; (-)-WR-171669) 是一种恶性疟原虫 (P. falciparum) 抑制剂，可靶向多重抗性的 P. falciparum。(-)-Halofantrine 在大鼠体内的药代动力学参数与给药途径差异性，并与其他异构体不同。

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(-)-Halofantrine Chemical Structure

(-)-Halofantrine Chemical Structure

CAS No. : 66051-76-1

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Other Forms of (-)-Halofantrine:

(-)-Halofantrine 相关抗体

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(-)-Halofantrine ((-)-SKF-102886 free base; (-)-WR-171669) is an inhibitor of the malignant malaria parasite (P. falciparum) and targets multidrug-resistant P. falciparum. The pharmacokinetic parameters of (-)-Halofantrine in rats vary depending on the route of administration, distinguishing it from other isomers[1].

IC50 & Target

P. falciparum[1]
体内研究
(In Vivo)

Halofantrine HCl在 大鼠空腹状态下的药代动力学数据[1][1]

Route Dose (mg/kg) Compound AUC0-∞ (mg·h/L) Cl (mL/h/kg) Vdss (L/kg) Vdβ (L/kg) t1/2 (h) Cmax (ng/mL) tmax (h)
i.v. 2; n=5 (-)-Halofantrine 5.02 199 3.22 4.64 16.8 / /
(+)-Halofantrine 9.06 113 2.38 3.13 20.8 / /
(±)-Halofantrine 14.1 143 3.53 3.60 18.0 / /
p.o. 14; n=5 (-)-Halofantrine 5.49 / / / 16.6 556 2.20
(+)-Halofantrine 16.3 / / / 16.5 917 4.20
(±)-Halofantrine 22.5 / / / 16.4 1420 3.60

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

500.42

Formula

C26H30Cl2F3NO
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(-)-Halofantrine 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

(-)-Halofantrine66051-76-1(-)-SKF-102886 (-)-WR-171669ParasiteInhibitorinhibitorinhibit

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