2. Metabolic Enzyme/Protease Apoptosis
  3. Glycosidase Apoptosis
  4. (-)-Pinoresinol

(-)-Pinoresinol 是一种植物来源的四氢呋喃木脂素，可抑制α-葡萄糖苷酶 (α-glucosidase)，作为降血糖剂。同时，(-)-Pinoresinol 也具有一定的抗炎作用，作为一种化学预防剂，诱导细胞凋亡 (apoptosis) 增加和细胞周期 G2/M停滞。

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(-)-Pinoresinol Chemical Structure

(-)-Pinoresinol Chemical Structure

CAS No. : 81446-29-9

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规格 价格 是否有货 数量
1 mg ￥1260
1 - 2 周
5 mg ￥4140
1 - 2 周
10 mg 现货 1 - 2 周
50 mg   询价  
100 mg   询价  

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Customer Review

(-)-Pinoresinol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(-)-Pinoresinol is a plant-derived tetrahydrofuran lignan that inhibits α-glucosidase and acts as a hypoglycemic agent. (-)-Pinoresinol has some anti-inflammatory effects and acts as a chemopreventive agent, inducing increased apoptosis and cell cycle G2/M arrest[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 100 μM
Compound: 41
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 18440233]
A549 IC50
> 30 μM
Compound: 9
Cytotoxicity against human A549 cells by SRB assay
Cytotoxicity against human A549 cells by SRB assay
[PMID: 26988298]
A549 IC50
> 40 μg/mL
Compound: 4
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
[PMID: 18603435]
B16-BL6 IC50
> 100 μM
Compound: 41
Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
[PMID: 18440233]
B16-F1 IC50
> 40 μg/mL
Compound: 4
Cytotoxicity against mouse B16F1 cells after 48 hrs by SRB assay
Cytotoxicity against mouse B16F1 cells after 48 hrs by SRB assay
[PMID: 18603435]
BMDC IC50
> 50 μM
Compound: 14
Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL12 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA
Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL12 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA
[PMID: 23484668]
BMDC IC50
> 50 μM
Compound: 14
Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated TNF-alpha production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA
Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated TNF-alpha production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA
[PMID: 23484668]
BMDC IC50
28.58 μM
Compound: 14
Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL-12p40 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA
Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL-12p40 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA
[PMID: 23484668]
BV-2 IC50
25.1 μM
Compound: 4; Pinoresinol
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
[PMID: 26774654]
BV-2 IC50
34.25 μM
Compound: 9
Anti-neuroinflammatory activity in LPS-activated mouse BV2 cells assessed as inhibition of NO production after 24 hrs by Griess assay
Anti-neuroinflammatory activity in LPS-activated mouse BV2 cells assessed as inhibition of NO production after 24 hrs by Griess assay
[PMID: 26988298]
HeLa IC50
92.5 μM
Compound: 41
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
[PMID: 18440233]
HL-60 IC50
> 10 μg/mL
Compound: 10
Cytotoxicity against human HL-60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL-60 cells after 72 hrs by MTT assay
[PMID: 10514313]
HT-1080 IC50
> 100 μM
Compound: 41
Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
[PMID: 18440233]
Lewis lung carcinoma cell line IC50
> 100 μM
Compound: 41
Cytotoxicity against mouse LLC cells after 72 hrs by MTT assay
Cytotoxicity against mouse LLC cells after 72 hrs by MTT assay
[PMID: 18440233]
N9 IC50
45.54 μM
Compound: 18
Antineuroinflammatory activity in mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
Antineuroinflammatory activity in mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
[PMID: 28073678]
RAW264.7 IC50
33.5 μM
Compound: 3
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
[PMID: 22079762]
RAW264.7 IC50
45.1 μM
Compound: 5
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
[PMID: 25592708]
SK-MEL-2 IC50
> 30 μM
Compound: 9
Cytotoxicity against human SK-MEL-2 cells by SRB assay
Cytotoxicity against human SK-MEL-2 cells by SRB assay
[PMID: 26988298]
SK-MEL-2 IC50
> 40 μg/mL
Compound: 4
Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay
Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay
[PMID: 18603435]
SK-OV-3 IC50
> 30 μM
Compound: 9
Cytotoxicity against human SKOV3 cells by SRB assay
Cytotoxicity against human SKOV3 cells by SRB assay
[PMID: 26988298]
XF498 IC50
> 30 μM
Compound: 9
Cytotoxicity against human XF498 cells by SRB assay
Cytotoxicity against human XF498 cells by SRB assay
[PMID: 26988298]
分子量

358.39

Formula

C20H22O6
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(-)-Pinoresinol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Pinoresinol81446-29-9GlycosidaseApoptosisGlycoside Hydrolasehypoglycemic agentanti-inflammatorychemopreventive agentapoptosisInhibitorinhibitorinhibit

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