2. Neuronal Signaling Stem Cell/Wnt
  3. γ-secretase
  4. MK-0752 sodium

MK-0752 sodium 是一种高效、口服活性的特异性 γ-分泌酶 (γ-secretase) 抑制剂，对人 SH-SY5Y 细胞 Aβ40 呈剂量依赖性降低，IC50 为 5 nM。MK-0752 sodium 穿过血脑屏障。MK-0752 sodium 降低体内新生的中枢神经系统 Aβ。

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MK-0752 sodium Chemical Structure

MK-0752 sodium Chemical Structure

CAS No. : 656810-87-6

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MK-0752 sodium 的其他形式现货产品:

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MK-0752 sodium 相关抗体

Top Publications Citing Use of Products

    MK-0752 sodium purchased from MCE. Usage Cited in: Andrologia. 2019 Nov;51(10):e13413.  [Abstract]

    MK-0752 regulated the expression of cell proliferation-related genes at the mRNA and protein levels. The relative protein expression of p27 and p21Waf1/Cip1 in TM3 Leydig cells after treatment with 25 μM MK-0752 respectively. The representative Western blots for p27 and p21Waf1/Cip1 after treatment with MK-0752.

    MK-0752 sodium purchased from MCE. Usage Cited in: EMBO Mol Med. 2017 Jul;9(7):950-966.  [Abstract]

    Turnover of endogenous CD74 P8 is inhibited by RO4929079 and BMS-906024. Cell lysate Western blot of A20 cells treated with GSIs is developed with In-1 antibody. MK-0752 and Semagacestat tests used the same control lane (0 nM).

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    MK-0752 sodium is a potent, orally active and specific γ-secretase inhibitor, showing dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells. MK-0752 sodium crosses the blood-brain barrier. MK-0752 sodium reduces newly generated CNS Aβ in vivo[1][2].

    分子量

    464.89

    Formula

    C21H20ClF2NaO4S
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    MK-0752 sodium 相关分类

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    • 稀释计算器

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    MK-0752656810-87-6MK0752MK 0752γ-secretaseGamma secretaseAβ40blood-brainbarrierCNSInhibitorinhibitorinhibit

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