2. Immunology/Inflammation
  3. Macrophage migration inhibitory factor (MIF)
  4. MKA031

MKA031 (compound 6y) 是一种非竞争性 MIF 抑制剂，其 IC50 值为 1.7 μM。 MKA031 能够干扰 MIF/AIF 相互作用、MIF 核易位和 N-甲基-N'-硝基-N-亚硝基胍 (MNNG) 诱导的依赖性细胞死亡。MKA031 可用于慢性丙型肝炎病毒感染的研究。

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MKA031 Chemical Structure

MKA031 Chemical Structure

CAS No. : 2951012-00-1

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MKA031 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MKA031 (compound 6y) is a non-competitive MIF inhibitor with an IC50 value of 1.7 μM. MKA031 (compound 6y) interferes with MIF/AIF interaction, MIF nuclear translocation, and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced dependent cell death. MKA031 can be used in the study of chronic hepatitis C virus infection[1].

体外研究
(In Vitro)

MKA031 (compound 6y) (1-100 μl;3 h) 阻止 MNNG 诱导的细胞死亡[1]。 MKA031 (compound 6y) (100 μl;3 h) 通过阻断 MIF 向 AIF 的募集来保护基因组 DNA[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MKA031 相关抗体:

Cell Viability Assay[1]

Cell Line: Hela cells
Concentration: 1-100 μM
Incubation Time: 3 h
Result: Protected HeLa cells from MNNG-induced parthanatos in a dose dependent manner with an EC50 of 7.7 μM.

Immunofluorescence[1]

Cell Line: Hela cells
Concentration: 100 μM
Incubation Time: 3 h
Result: Interfered with the MIF/AIF interaction and blocks MIF nuclear translocation.
分子量

403.46

Formula

C21H17N5O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MKA031 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MKA0312951012-00-1MKA 031MKA-031Macrophage migration inhibitory factor (MIF)Hepatitis CMNNGMIF/AIFparthanatosInhibitorinhibitorinhibit

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