2. Metabolic Enzyme/Protease PI3K/Akt/mTOR Apoptosis
  3. MMP Akt Apoptosis
  4. MMP-9-IN-4

MMP-9-IN-4 是一种 MMP-9 抑制剂 (IC50: 7.46 nM)，与 MMP-9 形成 H-π 相互作用。MMP-9-IN-4 还抑制 AKT 活性 (IC50: 8.82 nM)。MMP-9-IN-4 具有细胞毒性并诱导细胞凋亡 (apoptosis)。MMP-9-IN-4 可用于癌症研究。

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MMP-9-IN-4 Chemical Structure

MMP-9-IN-4 Chemical Structure

CAS No. : 2581824-39-5

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MMP-9-IN-4 相关抗体

Top Publications Citing Use of Products

查看 MMP 亚型特异性产品:

查看所有亚型
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MMP-9-IN-4 is a MMP-9 inhibitor (IC50: 7.46 nM) that has H-π interactions with MMP-9. MMP-9-IN-4 also inhibits AKT activity (IC50: 8.82 nM). MMP-9-IN-4 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-4 can be used in the research of cancers[1].

IC50 & Target[1]

MMP-9

7.46 nM (IC50)

MMP-1

41 nM (IC50)

MMP-2

139 nM (IC50)

MMP-13

113 nM (IC50)

AKT

8.82 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 IC50
2.2 nM
Compound: 11
Anticancer activity against human HepG2 cells assessed as reduction in cell viability by MTT assay
Anticancer activity against human HepG2 cells assessed as reduction in cell viability by MTT assay
[PMID: 31740054]
MCF7 IC50
3.6 nM
Compound: 11
Anticancer activity against human MCF7 cells assessed as reduction in cell viability by MTT assay
Anticancer activity against human MCF7 cells assessed as reduction in cell viability by MTT assay
[PMID: 31740054]
NFS-60 IC50
3.61 nM
Compound: 11
Anticancer activity against human NFS-60 cells assessed as reduction in cell viability by MTT assay
Anticancer activity against human NFS-60 cells assessed as reduction in cell viability by MTT assay
[PMID: 31740054]
WI-38 IC50
374 nM
Compound: 11
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability by MTT assay
[PMID: 31740054]
体外研究
(In Vitro)

MMP-9-IN-4 (compound 11, 0-1 μM approximately, 72 h) shows cytotoxicity to Wi-38, MCF-7, NFS-60, HepG-2 cells[1].
MMP-9-IN-4 (72 h) induces apoptosis in MCF-7, NFS-60 and HepG-2 cells at 3.6 nM, 3.61 nM, 2.2 nM respectively[1].
MMP-9-IN-4 (72 h) induces significant caspase 3/7 activation in MCF-7, NFS-60 and HepG-2 cells at 3.6 nM, 3.61 nM, 2.2 nM respectively [1].
MMP-9-IN-4 (2.2 nM, 24 h) inhibits cell migration in HepG-2 cells[1].
MMP-9-IN-4 has anti-bacterial activity against E.coli with a MIC value of 1.814 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MMP-9-IN-4 相关抗体:

Cell Viability Assay[1]

Cell Line: Wi-38, MCF-7, NFS-60, HepG-2 cells
Concentration: 0-1 μM approximately
Incubation Time: 72 h
Result: Showed cytotoxicity with IC50s: 374 nM (Wi-38), 3.6 nM (MCF-7), 3.61 nM (NFS-60), 2.2 nM (HepG-2).

Cell Migration Assay [1]

Cell Line: HepG-2
Concentration: 2.2 nM
Incubation Time: 24 h
Result: Inhibited cell migration by 93.77%.
分子量

564.47

Formula

C28H19F3N4O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MMP-9-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMP-9-IN-42581824-39-5MMPAktApoptosisMatrix metalloproteinasesPKBProtein kinase BCancertumorWi-38MCF-7NFS-60HepG-2cytotoxicitymigrationInhibitorinhibitorinhibit

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