2. MAPK/ERK Pathway Apoptosis
  3. MNK Apoptosis
  4. MNK1/2-IN-6

MNK1/2-IN-6 是一种有效的选择性的 MNK1/2 抑制剂，IC50s 分别为 2.3 nM 和 3.4 nM。 MNK1/2-IN-6 以浓度依赖性方式诱导细胞凋亡 apoptosis。

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MNK1/2-IN-6 Chemical Structure

MNK1/2-IN-6 Chemical Structure

CAS No. : 2771087-94-4

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MNK1/2-IN-6 相关抗体

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MNK1 MNK2 MNK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MNK1/2-IN-6 is a potent and selective MNK1/2 inhibitor with IC50s of 2.3 nM and 3.4 nM for MNK1 and MNK2, respectively. MNK1/2-IN-6 induces apoptosis in a concentration-dependent manner[1].

IC50 & Target[1]

MNK1

2.3 nM (IC50)

MNK2

3.4 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
DOHH-2 IC50
0.4092 μM
Compound: II-5
Antiproliferative activity against human DOHH-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human DOHH-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33971490]
TMD8 IC50
0.3896 μM
Compound: II-5
Antiproliferative activity against human TMD8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human TMD8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33971490]
体外研究
(In Vitro)

MNK1/2-IN-6 (compound II-5) (72 h) shows antiproliferative activity with IC50s of 0.3896µM, 0.4092 µM for TMD-8, DOHH-2 cells, respectively[1].
MNK1/2-IN-6 (0.25, 0.5, 1 µM; 24 h) induces TMD-8 cells apoptosis in a concentration-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MNK1/2-IN-6 相关抗体:

Cell Proliferation Assay[1]

Cell Line: TMD-8, DOHH-2 cells
Concentration:
Incubation Time: 72 h
Result: Showed antiproliferative activity with IC50s of 0.39µM, 0.41 µM for TMD-8, DOHH-2 cells, respectively.

Apoptosis Analysis[1]

Cell Line: TMD-8 cells
Concentration: 0.25, 0.5, 1 µM
Incubation Time: 24 h
Result: Induced TMD-8 cells apoptosis in a concentration-dependent manner.
分子量

448.52

Formula

C27H24N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MNK1/2-IN-6 相关分类

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Keywords:

MNK1/2-IN-62771087-94-4MNKApoptosisMitogen activated protein kinase interacting kinaseMAP kinase interacting kinaseMAPK interacting kinaseSelectiveantiproliferativeTMD-8 cellsDOHH-2 cellsapoptosisInhibitorinhibitorinhibit

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