2. Metabolic Enzyme/Protease Apoptosis
  3. Angiotensin-converting Enzyme (ACE) Apoptosis
  4. Moexipril

Moexipril  (Synonyms: 莫艾普利)

目录号: HY-117281
产品使用指南

摩尔计算器

Moexipril (莫艾普利) 是一种具有口服活性的血管紧张素转换酶 (ACE) 抑制剂，经水解为 moexiprilat 而发挥活性。Moexipril 具有降压和神经保护作用。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Moexipril hydrochloride 通常具有更好的水溶性和稳定性。

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Moexipril Chemical Structure

Moexipril Chemical Structure

CAS No. : 103775-10-6

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Moexipril 的其他形式现货产品:

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Moexipril 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Moexipril is an orally active inhibitor of angiotensin-converting enzyme (ACE), and becomes effective by being hydrolyzed to moexiprila (hydrochloride). Moexipril exhibits antihypertensive and neuroprotective effects[1]-[4].

IC50 & Target

IC50: 2.1 nM (purified ACE from rabbit lung), 1.75 nM (ACE in rat plasma)[3]
体外研究
(In Vitro)

Moexipril is devoid of anti-inflammatory properties and has no effect on platelet function[2].
Moexipril hydrolyzes to Moexiprilat, and Moexiprilat inhibits ACE in guinea pig serum as well as on purified ACE from rabbit lung with IC50s of 2.6 nM and 4.9 nM, respectively[2].
Moexipril (0.01 nM-0.1 mM) exhibits high potency against both ACE in rats plasma and purified ACE from rabbit lung, with IC50s of 1.75 nM and 2.1 nM, respectively[3].
Moexipril (0-100 μM, 24 h) significantly reduced the percentage of damaged neurons in a dose-dependent manner[4].
Moexipril (0-100 μM, 24 h) significantly attenuates Fe2+/3+-induced neurotoxicity[4].
Moexipril dose not cause significant changes in the percentage of apoptotic neurons[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Moexipril 相关抗体:
体内研究
(In Vivo)

Moexipril can not cross the blood-brain barrier[1].
Moexipril (3 mg/kg, 30 mg/kg and 10 mg/kg; p.o.; once daily; 5 days) exhibits a dose-dependent and antihypertensive effects in renal hypertensive rats, spontaneously hypertensive rats and perinephritic hypertensive dogs, respectively[3].
Moexipril (0.3 mg/kg, i.p.) significantly reduces the infarct area on the mouse brain surface in NMRI mice[4].
Moexipril (0.1 mg/kg, i.p.) significantly attenuates the cortical infarct volume in Long-Evans rats[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Spontaneously hypertensive rats[3]
Dosage: 30 mg/kg
Administration: Oral gavage; once daily; 5 days
Result: Caused a progressive lowering of mean blood pressure from pretreatment values of 180 +/- 7 mmHg to a trough on day 4 of 127 +/- 4 mmHg.
Dose-dependently decreased arterial blood pressure, and inhibited plasma and tissue ACE activity.
Animal Model: Renal hypertensive rats[3]
Dosage: 0.03-10 mg/kg
Administration: Oral gavage; once daily; 5 days
Result: Caused a dose-dependent decrease in blood pressure with a threshold dose of 0.3 mg/kg.
Lowered mean blood pressure by about 70 mmHg of 3 mg/kg.
Animal Model: Perinephritic hypertensive dogs[3]
Dosage: 10 mg/kg
Administration: Oral gavage; once daily; 5 days
Result: Caused a drop of mean blood pressure by 25 mmHg from pre-treatment control, which persisted for 24 h, by a rapid onset and a long duration of action.
Animal Model: NMRI mice (male, Permanent focal ischemia)[4]
Dosage: 0, 0.03, 0.3, and 3 mg/kg
Administration: Intraperitoneal injection (1 h before middle cerebral artery occlusion)
Result: Significantly reduced the infarct area on the mouse brain surface with a dose of 0.3 mg/kg, and other doses were not effective.
Animal Model: Long-Evans rats (male, Permanent focal ischemia)[4]
Dosage: 0, 0.01, 0.1 mg/kg
Administration: Intraperitoneal injection (1 h before middle cerebral artery occlusion)
Result: Significantly attenuated the cortical infarct volume from 114.4 to 98.2 mm as compared to non-treated animals in a dose of 0.01 mg/kg, without reducing the infarct volume of the rat brain at dosages >0.01 mg/kg.
Clinical Trial
分子量

498.57

Formula

C27H34N2O7
CAS 号
中文名称

莫艾普利
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Moexipril 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Moexipril103775-10-6莫艾普利Angiotensin-converting Enzyme (ACE)Apoptosisangiotensin IIhypertensionhydrochlorothiazidemoexiprilathepatic diseaseantihypertensivecardiovascular diseaseIschemic brain injuryorally activeessential hypertensionInhibitorinhibitorinhibit

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