2. GPCR/G Protein
  3. Mas-related G-protein-coupled Receptor (MRGPR)
  4. MRGPRX1 agonist 4

MRGPRX1 agonist 4 (compound 1t) 是一种有效且具有口服活性的 Mas 相关 G 蛋白偶联受体 X1 (MRGPRX1) 正向变构调节剂，EC50 为 0.1 μM。MRGPRX1 agonist 4 具有良好的代谢稳定性和口服生物利用度。在人源性 MRGPRX1 神经疼痛模型小鼠中，MRGPRX1 agonist 4 能降低行为性热过敏反应。MRGPRX1 agonist 4 可用于神经性疼痛的研究。

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MRGPRX1 agonist 4 Chemical Structure

MRGPRX1 agonist 4 Chemical Structure

CAS No. : 2764889-60-1

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MRGPRX1 agonist 4 相关抗体

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生物活性

MRGPRX1 agonist 4 (compound 1t) is a potent and orally active Mas-related G protein-coupled receptor X1 (MRGPRX1) positive allosteric modulator with an EC50 value of 0.1 μM. MRGPRX1 agonist 4 has good metabolic stability and oral bioavailability. MRGPRX1 agonist 4 can reduce behavioral heat hypersensitivity in a neuropathic pain model humanized MRGPRX1 mice. MRGPRX1 agonist 4 can be used for researching neuropathic pain[1].

IC50 & Target

EC50: 0.1 μM (MRGPRX1)[1]
分子量

513.36

Formula

C23H17Cl2F3N2O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MRGPRX1 agonist 4 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

MRGPRX1 agonist 42764889-60-1Mas-related G-protein-coupled Receptor (MRGPR)Neuropathic painBehavioral heat hypersensitivityCD 1 miceOrally activeInhibitorinhibitorinhibit

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产品名称：
MRGPRX1 agonist 4
目录号：
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