2. Stem Cell/Wnt
  3. Smo Hedgehog
  4. MRT-92

MRT-92 是一种 Smoothened (Smo) 拮抗剂 (Ki=0.7 nM)，具有抗癌活性。MRT-92 通过阻断 Smoothened 受体跨膜域中的重叠结合位点来抑制 Hedgehog 信号通路, 以及啮齿动物小脑颗粒细胞增殖 (IC50=0.4 nM)。MRT-92 可用于小脑神经胶质瘤的研究。

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MRT-92 Chemical Structure

MRT-92 Chemical Structure

CAS No. : 1428315-82-5

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MRT-92 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MRT-92 is a Smoothened (Smo) antagonist (Ki=0.7 nM) with anticancer activity. MRT-92 inhibits Hedgehog signaling pathway and rodent cerebellar granule cell proliferation by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor (IC50=0.4 nM). MRT-92 can be used in the study of cerebellar glioma[1].

分子量

566.65

Formula

C33H34N4O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MRT-92 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRT-921428315-82-5MRT92MRT 92SmoHedgehogSmoothenedsmoantagonisttransmembrane domaincerebellar granule cellsgliomaInhibitorinhibitorinhibit

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目录号：
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